Comparison of the efficacy of ivermectin, oxibendazole, and pyrantel pamoate against 28-day Parascaris equorum larvae in the intestine of pony foals

Scott M. Austin From the Departments of Veterinary Clinical Medicine (Austin, DiPietro, Foreman, Baker) and Veterinary Pathobiology (DiPietro, Todd), College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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 DVM, MS
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Joseph A. DiPietro From the Departments of Veterinary Clinical Medicine (Austin, DiPietro, Foreman, Baker) and Veterinary Pathobiology (DiPietro, Todd), College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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 DVM, MS
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Jonathan H. Foreman From the Departments of Veterinary Clinical Medicine (Austin, DiPietro, Foreman, Baker) and Veterinary Pathobiology (DiPietro, Todd), College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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Gordon J. Baker From the Departments of Veterinary Clinical Medicine (Austin, DiPietro, Foreman, Baker) and Veterinary Pathobiology (DiPietro, Todd), College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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Kenneth S. Todd Jr. From the Departments of Veterinary Clinical Medicine (Austin, DiPietro, Foreman, Baker) and Veterinary Pathobiology (DiPietro, Todd), College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

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 PhD

Summary

Sixteen helminth-free pony foals were inoculated with a mean (±sd) 2,000 (±545.5) infective Parascaris equorum eggs (day 0). Foals were allocated to replicates of 4, and treatments within each replicate were assigned at random. Treatment administered on postinoculation day (pid) 28 included no treatment (control), 0.2 mg of ivermectin/kg of body weight, 10 mg of oxibendazole/kg, or 6.6 mg of pyrantel base (pamoate)/kg. Paste formulations of the anthelmintics were administered orally. The foals were euthanatized 14 days after treatment (pid 42) and examined for P equorum larvae in the small intestine. The mean ± sd (and range) numbers of fourth-stage P equorum larvae recovered from nontreated foals and those treated with ivermectin, pyrantel, or oxibendazole were 1,603.8 ± 1,026.8 (305 to 2,480), 29.3 ± 55.8 (0 to 113), 413.0 ± 568.1 (0 to 1,204), or 889.5 ± 1,123.1 (1 to 2,345), respectively. Compared with the value for control (nontreated) foals, treatment with ivermectin, pyrantel, and oxibendazole was 98.2, 74.2, and 44.5% effective, respectively, when administered 28 days after experimentally induced infection with P equorum. Adverse reactions attributable to treatment were not observed.

Summary

Sixteen helminth-free pony foals were inoculated with a mean (±sd) 2,000 (±545.5) infective Parascaris equorum eggs (day 0). Foals were allocated to replicates of 4, and treatments within each replicate were assigned at random. Treatment administered on postinoculation day (pid) 28 included no treatment (control), 0.2 mg of ivermectin/kg of body weight, 10 mg of oxibendazole/kg, or 6.6 mg of pyrantel base (pamoate)/kg. Paste formulations of the anthelmintics were administered orally. The foals were euthanatized 14 days after treatment (pid 42) and examined for P equorum larvae in the small intestine. The mean ± sd (and range) numbers of fourth-stage P equorum larvae recovered from nontreated foals and those treated with ivermectin, pyrantel, or oxibendazole were 1,603.8 ± 1,026.8 (305 to 2,480), 29.3 ± 55.8 (0 to 113), 413.0 ± 568.1 (0 to 1,204), or 889.5 ± 1,123.1 (1 to 2,345), respectively. Compared with the value for control (nontreated) foals, treatment with ivermectin, pyrantel, and oxibendazole was 98.2, 74.2, and 44.5% effective, respectively, when administered 28 days after experimentally induced infection with P equorum. Adverse reactions attributable to treatment were not observed.

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