Evaluation of relationship between plasma fibrinogen concentration and tuberculin testing in red deer

J. P. Cross From the Microbiology Department, Medical School, University of Otago, PO Box 56, Dunedin, New Zealand (Cross, Reynolds, Griffin), and the Invermay Research Unit, Ministry of Agriculture and Fisheries, Private Bag, Mosgiel, New Zealand (Mackintosh).

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G. E. Reynolds From the Microbiology Department, Medical School, University of Otago, PO Box 56, Dunedin, New Zealand (Cross, Reynolds, Griffin), and the Invermay Research Unit, Ministry of Agriculture and Fisheries, Private Bag, Mosgiel, New Zealand (Mackintosh).

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C. G. Mackintosh From the Microbiology Department, Medical School, University of Otago, PO Box 56, Dunedin, New Zealand (Cross, Reynolds, Griffin), and the Invermay Research Unit, Ministry of Agriculture and Fisheries, Private Bag, Mosgiel, New Zealand (Mackintosh).

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J. F. T. Griffin From the Microbiology Department, Medical School, University of Otago, PO Box 56, Dunedin, New Zealand (Cross, Reynolds, Griffin), and the Invermay Research Unit, Ministry of Agriculture and Fisheries, Private Bag, Mosgiel, New Zealand (Mackintosh).

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Summary

After intradermal injection of bovine purified derivative (ppd), increases in plasma fibrinogen concentration and plasma viscosity developed in red deer (Cervus elaphus) with a history of tuberculosis caused by Mycobacterium bovis. Serum haptoglobin concentrations were also found to increase under similar circumstances. The increases were reproducible and did not appear to be related to mustering, stress, or the handling associated with injection of ppd. A significant (P < 0.05) direct relationship was found between the increase in plasma fibrinogen concentration and various markers of bovine tuberculosis infection, such as stimulation of lymphocyte transformation in response to bovine ppd and the diameter of intradermal tuberculin skin test reactions. A stronger correlation (P < 0.01) was found with the volume of intradermal tuberculin skin test reactivity, and the strongest correlation (P < 0.001) was with the presence of circulating antibovine ppd antibody.

Summary

After intradermal injection of bovine purified derivative (ppd), increases in plasma fibrinogen concentration and plasma viscosity developed in red deer (Cervus elaphus) with a history of tuberculosis caused by Mycobacterium bovis. Serum haptoglobin concentrations were also found to increase under similar circumstances. The increases were reproducible and did not appear to be related to mustering, stress, or the handling associated with injection of ppd. A significant (P < 0.05) direct relationship was found between the increase in plasma fibrinogen concentration and various markers of bovine tuberculosis infection, such as stimulation of lymphocyte transformation in response to bovine ppd and the diameter of intradermal tuberculin skin test reactions. A stronger correlation (P < 0.01) was found with the volume of intradermal tuberculin skin test reactivity, and the strongest correlation (P < 0.001) was with the presence of circulating antibovine ppd antibody.

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