Cerebrospinal fluid creatine kinase activity in horses with central nervous system disease: 69 cases (1984-1989)

Martin O. Furr From the Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061 (Furr), and Schering-Plough Research, Box 32, Rt 94, Lafayette, NJ 07848 (Tyler).

Search for other papers by Martin O. Furr in
Current site
Google Scholar
PubMed
Close
 DVM
and
Ronald D. Tyler From the Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061 (Furr), and Schering-Plough Research, Box 32, Rt 94, Lafayette, NJ 07848 (Tyler).

Search for other papers by Ronald D. Tyler in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Summary

The csf creatine kinase (ck) activity was determined in 70 csf samples from 69 horses with cns disease. Abnormal values (≥ 1 IU/L) were determined from 32 csf samples, and normal values (<1 IU/L) were found in 38 samples. Increased ck activity was most frequently associated with a diagnosis of equine protozoal myelitis; ck activity was not increased in 11 horses with cervical compressive myelopathy. Other diagnoses, in which csf ck activity was increased included trauma (n = 1), idiopathic epilepsy (n = 2), botulism (n = 2), articular facet fracture (n = 1), intervertebral disk protrusion (n = 1), and toxemia (n = 1).

Summary

The csf creatine kinase (ck) activity was determined in 70 csf samples from 69 horses with cns disease. Abnormal values (≥ 1 IU/L) were determined from 32 csf samples, and normal values (<1 IU/L) were found in 38 samples. Increased ck activity was most frequently associated with a diagnosis of equine protozoal myelitis; ck activity was not increased in 11 horses with cervical compressive myelopathy. Other diagnoses, in which csf ck activity was increased included trauma (n = 1), idiopathic epilepsy (n = 2), botulism (n = 2), articular facet fracture (n = 1), intervertebral disk protrusion (n = 1), and toxemia (n = 1).

Advertisement