Effect of otic medications containing glucocorticoids on liver function test results in healthy dogs

D. J. Meyer From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

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Karen A. Moriello From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

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Brett M. Feder From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

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Susan L. Fehrer-Sawyer From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

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Anna K. Maxwell From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

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Summary

Otic medications containing triamcinolone or dexamethasone were administered twice daily for 21 days to 2 groups of 4 healthy dogs each. Serum alkaline phosphatase, γ-glutamyltransferase, alanine transaminase, and aspartate transaminase activities, and serum bile acid and lipoprotein-X concentrations were assayed for 35 days.

Increased serum activities for γ-glutamyltransferase, alkaline phosphatase, and alanine transaminase were detected by day 7 and peaked at day 21. Increases were greater in dogs given the dexamethasone-containing medication. Enzyme activity returned to baseline by day 35. Serum aspartate transaminase activity and bile acid and lipoprotein-X concentrations did not increase.

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Cover Journal of the American Veterinary Medical Association
Journal of the American Veterinary Medical Association
Issue:
01 Mar 1990
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