Effect of otic medications containing glucocorticoids on liver function test results in healthy dogs

D. J. Meyer From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

Search for other papers by D. J. Meyer in
Current site
Google Scholar
PubMed
Close
 DVM
,
Karen A. Moriello From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

Search for other papers by Karen A. Moriello in
Current site
Google Scholar
PubMed
Close
 DVM
,
Brett M. Feder From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

Search for other papers by Brett M. Feder in
Current site
Google Scholar
PubMed
Close
 DVM
,
Susan L. Fehrer-Sawyer From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

Search for other papers by Susan L. Fehrer-Sawyer in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Anna K. Maxwell From the Department of Medical Sciences, Box J-126, College of Veterinary Medicine, University of Florida, Gainesville, FL32610.

Search for other papers by Anna K. Maxwell in
Current site
Google Scholar
PubMed
Close
 BS

Summary

Otic medications containing triamcinolone or dexamethasone were administered twice daily for 21 days to 2 groups of 4 healthy dogs each. Serum alkaline phosphatase, γ-glutamyltransferase, alanine transaminase, and aspartate transaminase activities, and serum bile acid and lipoprotein-X concentrations were assayed for 35 days.

Increased serum activities for γ-glutamyltransferase, alkaline phosphatase, and alanine transaminase were detected by day 7 and peaked at day 21. Increases were greater in dogs given the dexamethasone-containing medication. Enzyme activity returned to baseline by day 35. Serum aspartate transaminase activity and bile acid and lipoprotein-X concentrations did not increase.

Summary

Otic medications containing triamcinolone or dexamethasone were administered twice daily for 21 days to 2 groups of 4 healthy dogs each. Serum alkaline phosphatase, γ-glutamyltransferase, alanine transaminase, and aspartate transaminase activities, and serum bile acid and lipoprotein-X concentrations were assayed for 35 days.

Increased serum activities for γ-glutamyltransferase, alkaline phosphatase, and alanine transaminase were detected by day 7 and peaked at day 21. Increases were greater in dogs given the dexamethasone-containing medication. Enzyme activity returned to baseline by day 35. Serum aspartate transaminase activity and bile acid and lipoprotein-X concentrations did not increase.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 460 460 21
PDF Downloads 52 52 7
Advertisement