Clinical and immunologic response of cattle to administration of a vaccine containing modified-live bovine respiratory syncytial virus

J.A. Ellis From the Department of Veterinary Sciences, College of Agriculture, University of Wyoming, 1190 Jackson St, Laramie, WY 82070 (Ellis, Pratt), the Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 (Davis), and Norden Laboratories, Lincoln, NE 68521 (Talens).

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W.C. Davis From the Department of Veterinary Sciences, College of Agriculture, University of Wyoming, 1190 Jackson St, Laramie, WY 82070 (Ellis, Pratt), the Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 (Davis), and Norden Laboratories, Lincoln, NE 68521 (Talens).

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L. Talens From the Department of Veterinary Sciences, College of Agriculture, University of Wyoming, 1190 Jackson St, Laramie, WY 82070 (Ellis, Pratt), the Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 (Davis), and Norden Laboratories, Lincoln, NE 68521 (Talens).

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D.L. Pratt From the Department of Veterinary Sciences, College of Agriculture, University of Wyoming, 1190 Jackson St, Laramie, WY 82070 (Ellis, Pratt), the Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 (Davis), and Norden Laboratories, Lincoln, NE 68521 (Talens).

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Summary

Healthy yearling beef and dairy cattle were inoculated with a vaccine containing modified-live bovine respiratory syncytial virus (ml-brsv), and sequential changes in clinical signs of disease, blood leukocyte subsets, brsv-specific antibody titer, and in vitro lymphocyte blastogenic responses were monitored. Vaccination with ml-brsv did not cause pyrexia, local or systemic hypersensitivity reaction, or respiratory tract disease. Episodes of leukopenia, abnormalities in lymphocyte subsets, or depression of phytomitogen-induced blastogenic responses were not observed subsequent to vaccination. Exposure to ml-brsv resulted in at least a 16-fold increase in serum neutralizing antibody titer, with no increase seen in nonvaccinated contact controls. Significant brsv-specific lymphocyte blastogenic responses were not detected, using one dose of several brsv antigen preparations in a whole blood culturing system.

Summary

Healthy yearling beef and dairy cattle were inoculated with a vaccine containing modified-live bovine respiratory syncytial virus (ml-brsv), and sequential changes in clinical signs of disease, blood leukocyte subsets, brsv-specific antibody titer, and in vitro lymphocyte blastogenic responses were monitored. Vaccination with ml-brsv did not cause pyrexia, local or systemic hypersensitivity reaction, or respiratory tract disease. Episodes of leukopenia, abnormalities in lymphocyte subsets, or depression of phytomitogen-induced blastogenic responses were not observed subsequent to vaccination. Exposure to ml-brsv resulted in at least a 16-fold increase in serum neutralizing antibody titer, with no increase seen in nonvaccinated contact controls. Significant brsv-specific lymphocyte blastogenic responses were not detected, using one dose of several brsv antigen preparations in a whole blood culturing system.

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