Drug-associated aplastic anemia in dogs: Eight cases (1984-1988)

Douglas J. Weiss From the Departments of Veterinary Pathobiology (Weiss) and Small Animal Clinical Sciences (Klausner), College of Veterinary Medicine, University of Minnesota, 205 Veterinary Science, 1971 Commonwealth Ave, St. Paul, MN 55108.

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 DVM, PhD
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Jeffrey S. Klausner From the Departments of Veterinary Pathobiology (Weiss) and Small Animal Clinical Sciences (Klausner), College of Veterinary Medicine, University of Minnesota, 205 Veterinary Science, 1971 Commonwealth Ave, St. Paul, MN 55108.

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 DVM, MS

Summary

Records of 8 dogs with drug-associated aplastic anemia were reviewed. Drugs suspected as being causative included estradiol cyclopentylpropionate (3 dogs), phenylbutazone (2 dogs), meclofenamic acid (1 dog), trimethoprim-sulfadiazine and fenbendazole (1 dog), and quinidine (1 dog). Five of the dogs died or were euthanatized. One dog with estrogen-associated aplasia recovered after prolonged treatment. The dogs with trimethoprim-sulfadiazine and quinidine-associated marrow aplasia recovered promptly after treatment was discontinued.

Summary

Records of 8 dogs with drug-associated aplastic anemia were reviewed. Drugs suspected as being causative included estradiol cyclopentylpropionate (3 dogs), phenylbutazone (2 dogs), meclofenamic acid (1 dog), trimethoprim-sulfadiazine and fenbendazole (1 dog), and quinidine (1 dog). Five of the dogs died or were euthanatized. One dog with estrogen-associated aplasia recovered after prolonged treatment. The dogs with trimethoprim-sulfadiazine and quinidine-associated marrow aplasia recovered promptly after treatment was discontinued.

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