Effects of propylene glycol-containing diets on acetaminophen-induced methemoglobinemia in cats

Douglas J. Weiss From the Departments of Veterinary Pathobiology (Weiss, McClay, Perman) and Diagnostic Investigation (Murphy), College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, and the Division of Hematology, Department of Medicine, Box 480 UMHC, University of Minnesota, Minneapolis, MN 55455 (Christopher).

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Carolyn B. McClay From the Departments of Veterinary Pathobiology (Weiss, McClay, Perman) and Diagnostic Investigation (Murphy), College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, and the Division of Hematology, Department of Medicine, Box 480 UMHC, University of Minnesota, Minneapolis, MN 55455 (Christopher).

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Mary M. Christopher From the Departments of Veterinary Pathobiology (Weiss, McClay, Perman) and Diagnostic Investigation (Murphy), College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, and the Division of Hematology, Department of Medicine, Box 480 UMHC, University of Minnesota, Minneapolis, MN 55455 (Christopher).

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Micheal Murphy From the Departments of Veterinary Pathobiology (Weiss, McClay, Perman) and Diagnostic Investigation (Murphy), College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, and the Division of Hematology, Department of Medicine, Box 480 UMHC, University of Minnesota, Minneapolis, MN 55455 (Christopher).

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Victor Perman From the Departments of Veterinary Pathobiology (Weiss, McClay, Perman) and Diagnostic Investigation (Murphy), College of Veterinary Medicine, University of Minnesota, 1971 Commonwealth Ave, St Paul, MN 55108, and the Division of Hematology, Department of Medicine, Box 480 UMHC, University of Minnesota, Minneapolis, MN 55455 (Christopher).

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Summary

Soft-moist cat foods contain 7 to 13% propylene glycol (PG) on a dry-weight basis. These diets induce Heinz body formation in feline RBC. In this study, we evaluated cats on a control diet and on a commercial diet containing 8.3% PG. All cats on the PG diet developed an increase in the number of circulating Heinz bodies. We then administered acetaminophen to cats on each diet to determine whether RBC from cats on PG diets were more susceptible to oxidant stress. Methemoglobin concentrations were significantly greater in cats in PG diets after acetaminophen administration. These data indicate that RBC from cats fed PG diets are more susceptible to oxidative stress.

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Cover Journal of the American Veterinary Medical Association
Journal of the American Veterinary Medical Association
Issue:
01 Jun 1990
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