21st century research—One Health, resilience, welfare, and disease

Kristen K. Reyher University of Bristol, Bristol, UK

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 DVM, PhD
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Kate Allen University of Bristol, Bristol, UK

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 BVSc, PhD, DACVSMR
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Mick Bailey University of Bristol, Bristol, UK

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 BVSc, PhD
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Andrew Dowsey University of Bristol, Bristol, UK

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Melanie Hezzell University of Bristol, Bristol, UK

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 VetMB, PhD, DACVIM (Cardiology)
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Sarah Lambton University of Bristol, Bristol, UK

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Jamie Mann University of Bristol, Bristol, UK

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Michael Mendl University of Bristol, Bristol, UK

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 PhD
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Laura Peachey University of Bristol, Bristol, UK

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 BVSc, PhD
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Tim Parkin University of Bristol, Bristol, UK

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 BVSc, PhD, DipECVPH

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Research at Bristol Veterinary School (BVS) accesses leading-edge technologies to investigate fundamental and applied research questions underpinning global challenges in population health and global food security. Our goals are to improve immediate and future health of humans and animals by achieving the following:

  • Increasing sustainable production of healthy, high-welfare food while supporting recovery of endangered environmental resources

  • Ensuring sustainable use of medicines

  • Reducing impact of bacterial, viral, and parasitic zoonotic diseases

  • Translating developments across fundamental research into novel management and therapeutic approaches

Our research is strengthened by the overlap between these goals and our multidisciplinary approaches.

BVS has a history of world-leading research in animal welfare and behavior. This spans farm, laboratory, companion, and wild animals, including fundamental underpinning studies of behavior, cognition and emotion, development of new ways to assess animal affective states and welfare, work aimed at minimizing welfare and behavior problems in situ, and integrating welfare considerations into sustainable agriculture. Other research assesses how companion animals impact human well-being and vice versa. We work closely with stakeholders to implement changes in practices using approaches from psychology, ethics, and social science.

The Infection, Inflammation, and Immunotherapy research community spans immunology, microbiology, animal microbiomes, mathematical modelling, and infectious diseases. Studies of SARS-CoV-2 in aerosols actively contribute to understanding droplet spread in clinical areas. Research includes controlled intervention and/or infection experiments complementary to industry-relevant, farm-based facilities such as poultry and dairy farms, HIV vaccinology, equine anthelmintic resistance surveillance, and investigations into the development and epidemiology of animal microbiomes. Facilities for monitoring surgical implants as well as containment facilities suitable for faecal-orally and aerosol-transmitted organisms are used for work with infectious diseases.

BVS researchers are world-renowned for their work on antimicrobial resistance (AMR) and lead a number of large collaborative projects on antimicrobial use, stewardship, and resistance. Researchers take an holistic overview of epidemiology data sets and use a range of technical methods to evaluate use and resistance as well as AMR drivers on farms across 3 continents. A large, vibrant, and internationally focused research group, they study the transmission and evolution of AMR from an One Health perspective and lead impactful events including dissemination of outcomes to farmers, veterinarians, policymakers, and other interested stakeholders.

F1

Cross-cutting and interwoven research themes and communities define our interdisciplinary One Health research.

Citation: American Journal of Veterinary Research 83, 8; 10.2460/ajvr.22.06.0101

Our Veterinary Clinical research community undertakes cutting-edge research underpinned by comparative approaches and collaborations with world-leading groups. Two longitudinal cohort studies (Bristol Cats and the Mitral Valve Clinic) provide insights into the epidemiology, genetics, and molecular pathogenesis of disease. Our major equine research themes are optimisation of the health, welfare, and performance of racehorses and sports horses, parasitology, and microbiomes. Research focuses on cardiology, oncology, nephrology, endothelial health in chronic disease, critically ill patients, and infectious disease. These streams aim to understand disease risk and molecular pathogenesis as well as to devise novel diagnostics and therapeutics.

Our work is underpinned by experts in statistical data science, artificial intelligence, epidemiology, animal biometrics, and genome bioinformatics. These digital researchers codevelop studies with core research communities, interpreting big data from deep omics profiling to large epidemiological data sets.

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