Body temperature in dogs should be maintained within the reference range during most surgical procedures and the postoperative period to avoid the potential adverse sequelae of hypothermia, such as prolonged coagulation times and altered wound healing.1–3 Opioids act on the thermoregulation center, which is located in the hypothalamus, resulting in a shift of the thermoregulatory set point and a decrease in body temperature.4
Combinations of lidocaine hydrochloride and ketamine hydrochloride with morphine (MLK combination) or fentanyl (FLK combination) have been routinely used for analgesia during and after procedures in dogs treated at the National Chung Hsing University Veterinary Medical Teaching Hospital. In the past few years, we have observed lower postprocedure body temperatures in dogs that received the MLK combination for postprocedure analgesia than in dogs that received the FLK combination. However, to the authors’ knowledge, the effects of the FLK and MLK combinations on body temperature of dogs have not been reported. The objective of the study reported here was to compare the effects of MLK and FLK combinations administered as CRIs during and after procedures on postprocedure rectal temperature in dogs.
This manuscript represents a portion of a thesis submitted by Dr. Chuang to the National Chung Hsing University, Department of Veterinary Medicine as partial fulfillment of the requirements for a Master of Science degree.
No third-party funding or support was received in connection with this study or the writing or publication of the manuscript, and the authors declare that there were no conflicts of interest.
Constant rate infusion
Mean arterial blood pressure
Morphine, Taiwan Food and Drug Administration, New Taipei, Taiwan.
Fentanyl, Taiwan Food and Drug Administration, New Taipei, Taiwan.
Dormicum, Roche Inc, Basel, Switzerland.
Propofol-Lipuro 1%, B. Braun Melsungen AG, Melsungen, Ger many.
Ketamine hydrochloride Imalgene 1000, Merial, Lyon, France.
Xylocaine 2%, Cenexi, Fontenay-sous-Bois, France.
Flyhorse clinical mercury thermometer, Shanghai Hua Chen Medical Instruments Co Ltd, Shanghai, China.
VET-HDO monitor, S + B medVET GmbH, Babenhausen, Germany.
Wisewind thermostat, Wisewind Enterprise Co Ltd, Taipei, Taiwan.
SPSS Statistics, version 20.0, IBM Corp, Armonk, NY.
1. Yoshihara H, Yamamoto T, Mihara H. Changes in coagulation and fibrinolysis occurring in dogs during hypothermia. Thromb Res 1985;37:503–512.
2. Brodeur A, Wright A, Cortes Y. Hypothermia and targeted temperature management in cats and dogs. J Vet Emerg Crit Care (San Antonio) 2017;27:151–163.
3. Armstrong SR, Roberts BK, Aronsohn M. Perioperative hypothermia. J Vet Emerg Crit Care (San Antonio) 2005;15:32–37.
4. Adler MW, Geller EB, Rosow CE, et al. The opioid system and temperature regulation. Annu Rev Pharmacol Toxicol 1988;28:429–449.
5. Schulte am Esch J, Pfeifer G, Thiemig I, et al. The influence of intravenous anaesthetic agents on primarily increased intracranial pressure. Acta Neurochir (Wien) 1978;45:15–25.
6. Lefebvre RA, Willems JL, Bogaert MG. Gastric relaxation and vomiting by apomorphine, morphine and fentanyl in the conscious dog. Eur J Pharmacol 1981;69:139–145.
7. Matsukawa T, Sessler DI, Christensen R, et al. Heat flow and distribution during epidural anesthesia. Anesthesiology 1995;83:961–967.
9. Holden D. Paediatric patients In: Seymour C, Duke-Novakovski T, eds. BSAVA manual of canine and feline anaesthesia and analgesia. 2nd ed. Gloucester, England: British Small Animal Veterinary Association, 2007;296–302.
10. Davis H, Jensen T, Johnson A, et al. 2013 AAHA/AAFP fluid therapy guidelines for dogs and cats. J Am Anim Hosp Assoc 2013;49:149–159.
11. Pekcan Z, Koc B. The post-operative analgesic effects of epidurally administered morphine and transdermal fentanyl patch after ovariohysterectomy in dogs. Vet Anaesth Analg 2010;37:557–565.
12. Reid J, Nolan A, Hughes J, et al. Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. Anim Welf 2007;16:97–104.
13. Clark WG, Clark YL. Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents. Neurosci Biobehav Rev 1980;4:175–240.
14. Clark WG, Lipton J. Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents: II. Neurosci Biobehav Rev 1985;9:479–552.
15. Lucas AN, Firth AM, Anderson GA, et al. Comparison of the effects of morphine administered by constant-rate intravenous infusion or intermittent intramuscular injection in dogs. J Am Vet Med Assoc 2001;218:884–891.
16. Guedes AG, Papich MG, Rude EP, et al. Pharmacokinetics and physiological effects of two intravenous infusion rates of morphine in conscious dogs. J Vet Pharmacol Ther 2007;30:224–233.
17. Redondo JI, Suesta P, Serra I, et al. Retrospective study of the prevalence of postanaesthetic hypothermia in dogs. Vet Rec 2012;171:374.
18. Kongsayreepong S, Chaibundit C, Chadpaibool J, et al. Predictor of core hypothermia and the surgical intensive care unit. Anesth Analg 2003;96:826–833.
19. Chen JC, Smith ER, Cahill M, et al. The opioid receptor binding of dezocine, morphine, fentanyl, butorphanol and nalbuphine. Life Sci 1993;52:389–396.
20. Gharagozlou P, Hashemi E, DeLorey TM, et al. Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacol 2006;6:3.
21. Lester PA, Traynor JR. Comparison of the in vitro efficacy of μ, Δ, κ and ORL1 receptor agonists and non-selective opioid agonists in dog brain membranes. Brain Res 2006;1073–1074:290–296.
22. Baker AK, Meert TF. Functional effects of systemically administered agonists and antagonists of μ, Δ, and κ opioid receptor subtypes on body temperature in mice. J Pharmacol Exp Ther 2002;302:1253–1264.
23. Glosten B, Sessler D, Ostman L, et al. Intravenous lidocaine does not cause shivering-like tremor or alter thermoregulation. Reg Anesth 1991;16:218–222.
24. Boscan P, Pypendop BH, Solano AM, et al. Cardiovascular and respiratory effects of ketamine infusions in isoflurane-anesthetized dogs before and during noxious stimulation. Am J Vet Res 2005;66:2122–2129.
26. Ikeda T, Kazama T, Sessler DI, et al. Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia. Anesth Analg 2001;93:934–938.
27. Kinoshita T, Suzuki M, Shimada Y, et al. Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol. J Nippon Med Sch 2004;71:92–98.