Book Reviews

Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research

Robert Lewis Maynard, BSc, MB, BCh, & Noel Downes, BDS

359 pages. 2019. Academic Press (an imprint of Elsevier). ISBN 978-0-12-811837-5. Price $170.00.

In the preface of Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research, the authors clearly state that it is not intended to be a reference textbook but rather a book that provides a comparative overview of rat anatomy, with an emphasis on tissue form and function. The chapters are thoughtfully organized in a systems-based approach that evolves into more detailed chapters, which highlight specific tissues and organ systems that are commonly viewed as target organs in toxicity and carcinogenicity studies. The tables and diagrams are particularly useful as are the comprehensive bibliographies included at the end of each chapter. However, it is important to note that this book is not an atlas; the histology component of the text is mostly descriptive. The few photomicrographs that are included are generally not of the best image quality and often lack detail (eg, information regarding type of stain used, magnification, and scale bars is often not provided). For this reason, this book may not be an appropriate introductory textbook for those unfamiliar with histologic interpretation.

The book is reasonably priced, and the target audience as indicated by the authors is graduate students studying toxicology and those working in the areas of zoology, anatomy, physiology, experimental pathology, and immunology. Laboratory technicians or assistants and undergraduate or veterinary students interested in learning more about comparative rat anatomy and dissection techniques will also find this book useful.

Reviewed by Erin M. Quist, DVM, PhD, DACVP

Experimental Pathology Laboratories Inc

Research Triangle Park, NC

Ectoparasites: Drug Discovery Against Moving Targets

Charles Q. Meng, PhD, & Ann E. Sluder, PhD

360 pages. 2018. Wiley-VCH Verlag GmbH & Co. ISBN 978-3-527-34168-9. Price $205.00.

Ectoparasites: Drug Discovery Against Moving Targets is the eighth volume of a series entitled Drug Discovery in Infectious Diseases. This book provides an excellent review of the development, evaluation, and use of insecticides, acaricides, and vaccines against ectoparasites. The book focuses primarily on ectoparasites of importance in veterinary medicine. The 1 exception is the chapter on drug development for the control of human lice, which is an excellent review but seems out of place in this book. The rest of the book is devoted to the development of drugs and vaccines to control external parasites of importance to veterinary medicine. It will be a valuable resource for specialists in veterinary parasitology, pharmacology, and dermatology. Of particular value is that the entire book has extensive referencing of source material, which is not found in most books. This allows readers to research relevant references and expand their knowledge on specific topics including the design of in vitro and in vivo methods to develop and evaluate drugs that treat external parasites. Although the topics in the first sections of the book may primarily interest specialists, the latter chapters of the book on the isoxazolines will be of use to practicing veterinarians. The isoxazoline class of drugs including afoxolaner, fluralaner, lotilaner, and sarolaner is currently revolutionizing the control of external parasites. The last 5 chapters on the discovery and development of afoxolaner and sarolaner are very detailed and provide excellent information on the mode of action, metabolism, and efficacy of this new class of ectoparasitic drugs.

Reviewed by Michael W. Dryden, DVM, PhD, DACVM

Kansas State University

Manhattan, Kan