Book Review

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Microbial Efflux Pumps: Current Research

Edward W. Yu, Qijing Zhang, & Melissa H. Brown

257 pages. 2013. Caister Academic Press, distributed by International Specialized Book Services. ISBN 978-1-908230-21-8. Price $319.00.

Microbial Efflux Pumps: Current Research provides a detailed description of the efflux pumps used for cellular export in both simple and complex organisms. It does an excellent job of highlighting the conserved basic structure of these proteins across kingdoms as well as how genes encoding these proteins in lower organisms including bacteria have been mutated, duplicated, or inverted for use in eukaryotes. The early chapters of the book address the structure and function of the major categories of efflux pumps and how they act to perform normal processes from ion flux to neurotransmitter release. Included in these chapters are highly detailed descriptions of well-characterized efflux machinery and how these protein complexes provide polyspecificity for compound export, with specific implications for conferring resistance to heavy metals, environmental hazards (bile salts, detergents, and solvents), and therapeutic drugs. The remaining chapters of the book discuss examples of potential high-consequence pathogens, with descriptions of the discoveries related to the specific processes these microbes use to evade chemical treatment and produce compounds that damage competing organisms. In the Plate section, x-ray structures are provided in color, which makes understanding efflux pump construction and chemical interactions easier to visualize than do black-and-white diagrams in the text.

This text provides valuable information about the mechanisms of microbial and cellular drug resistance development. It will be useful to research scientists investigating microbial and cellular adaptation, for pharmaceutical experts evaluating potential chemotherapeutic compounds, and for clinicians wanting to understand the mechanisms of drug resistance and reasons for treatment failure.

Reviewed by Kristin A. Clothier, DVM, PhD, DACVM

University of California-Davis Davis, Calif

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