In cats, IC is a chronic disease that results in clinical signs related to the urinary bladder such as changes in urinary frequency, urinary urgency, and inappropriate urinations. The cause of the disease in cats is unknown, although abnormalities in the nervous1–3 and endocrine4 systems have been documented. Furthermore, studies have revealed abnormalities related to alterations in urinary bladder permeability5,6 that may be mediated by the sympathetic nervous system.3,7–9
Humans can develop a chronic disease termed PBS-IC, the nature of which appears similar to that of IC in cats.10 Diagnostic tests for both species include urinalysis, bacterial culture of urine, and imaging to rule out cystic calculi or neoplasia as the cause for the clinical signs. In humans, urodynamic evaluations also can be performed to identify OAB, which can be a separate or concurrent abnormality in humans with PBSIC.11 Urodynamic evaluations may be useful for establishing the presence of muscle overactivity11 or urinary bladder outlet obstruction in patients with lower urinary tract signs.12 Although urodynamic procedures are not routinely performed in cats, advances in equipment and standardized protocols13 have made such diagnostic methodologies increasingly available. The purpose of the study reported here was to evaluate urodynamic parameters in cats with IC and compare these data with previously published data for healthy cats obtained by the same research group with the same anesthetic protocols and equipment.13
Constant rate infusion
Maximum urethral closure pressure
Maximum urethral pressure
Overactive urinary bladder
Painful bladder syndrome-interstitial cystitis
Propoflo, Abbott Animal Health, North Chicago, Ill.
Isoflo, Abbott Animal Health, North Chicago, Ill.
Urovision Janus V system, Life-Tech Inc, Stafford, Tex.
DLc-gP, Life-Tech Inc, Stafford, Tex.
Westropp JL, Kass PH, Buffington CA. Evaluation of the effects of stress in cats with idiopathic cystitis. Am J Vet Res 2006; 67:731–736.
Westropp JL, Kass PH, Buffington CA. In vivo evaluation of alpha(2)-adrenoceptors in cats with idiopathic cystitis. Am J Vet Res 2007; 68:203–207.
Sculptoreanu A, de Groat WC, Buffington CA, et al. Abnormal excitability in capsaicin-responsive DRG neurons from cats with feline interstitial cystitis. Exp Neurol 2005; 193:437–443.
Lavelle JP, Meyers SA, Ruiz WG, et al. Urothelial pathophysiological changes in feline interstitial cystitis: a human model. Am J Physiol Renal Physiol 2000; 278:F540–F553.
Buffington CA, Blaisdell JL, Binns SP Jr, et al. Decreased urine glycosaminoglycan excretion in cats with interstitial cystitis. J Urol 1996; 155:1801–1804.
Birder LA, Barrick SR, Roppolo JR, et al. Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol 2003; 285:F423–F429.
Birder LA, Nealen ML, Kiss S, et al. Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci 2002; 22:8063–8070.
Birder LA, Ruan HZ, Chopra B, et al. Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 2004; 287:F1084–F1091.
Dell JR, Mokrzycki ML, Jayne CJ. Differentiating interstitial cystitis from similar conditions commonly seen in gynecologic practice. Eur J Obstet Gynecol Reprod Biol 2009; 144:105–109.
Cameron AP, Gajewski JB. Bladder outlet obstruction in painful bladder syndrome/interstitial cystitis. Neurourol Urodyn 2009; 28:944–948.
Cohen TA, Westropp JL, Kass PH, et al. Evaluation of urodynamic procedures in female cats anesthetized with low and high doses of isoflurane and propofol. Am J Vet Res 2009; 70:290–296.
Gregory CR, Willits NH. Electromyographic and urethral pressure evaluations: assessment of urethral function in female and ovariohysterectomized female cats. Am J Vet Res 1986; 47:1472–1475.
Hanno P, Dmochowski R. Status of international consensus on interstitial cystitis/bladder pain syndrome/painful bladder syndrome: 2008 snapshot. Neurourol Urodyn 2009; 28:274–286.
Forrest JB, Moldwin R. Diagnostic options for early identification and management of interstitial cystitis/painful bladder syndrome. Int J Clin Pract 2008; 62:1926–1934.
Kim SH, Kim TB, Kim SW, et al. Urodynamic findings of the painful bladder syndrome/interstitial cystitis: a comparison with idiopathic overactive bladder. J Urol 2009; 181:2550–2554.
Awad SA, MacDiarmid S, Gajewski JB, et al. Idiopathic reduced bladder storage versus interstitial cystitis. J Urol 1992; 148:1409–1412.
Macdiarmid SA, Sand PK. Diagnosis of interstitial cystitis/painful bladder syndrome in patients with overactive bladder symptoms. Rev Urol 2007; 9:9–16.
Straeter-Knowlen IM, Marks SL, Rishniw M, et al. Urethral pressure response to smooth and skeletal muscle relaxants in anesthetized, adult male cats with naturally acquired urethral obstruction. Am J Vet Res 1995; 56:919–923.
Minaglia S, Ozel B, Bizhang R, et al. Increased prevalence of interstitial cystitis in women with detrusor overactivity refractory to anticholinergic therapy. Urology 2005; 66:702–706.
Roppolo JR, Tai C, Booth AM, et al. Bladder Adelta afferent nerve activity in normal cats and cats with feline interstitial cystitis. J Urol 2005; 173:1011–1015.
Rovner E, Propert KJ, Brensinger C, et al. Treatments used in women with interstitial cystitis: the interstitial cystitis data base (ICDB) study experience. The Interstitial Cystitis Data Base Study Group. Urology 2000; 56:940–945.
Webster JR. Combined video/pressure/flow cystourethrog-raphy in female patients with voiding disturbances. Urology 1975; 5:209–215.
Yoshimura N, Seki S, Chancellor MB, et al. Targeting afferent hyperexcitability for therapy of the painful bladder syndrome. Urology 2002; 59:61–67.
Akamatsu T, Fukuyama H, Kawamata T. The effects of visual, auditory, and mixed cues on choice reaction in Parkinson's disease. J Neurol Sci 2008; 269:118–125.
Mehnert U, Knapp PA, Mueller N, et al. Heart rate variability: an objective measure of autonomic activity and bladder sensations during urodynamics. Neurourol Urodyn 2009; 28:313–319.
Ness TJ, Powell-Boone T, Cannon R, et al. Psychophysical evidence of hypersensitivity in subjects with interstitial cystitis. J Urol 2005; 173:1983–1987.