Effect of marbofloxacin on cardiovascular variables in healthy isoflurane-anesthetized dogs

Guillaume P. Chanoit UMR INRA Physiopathologie et Toxicologie Expérimentales, Ecole Vétérinaire de Toulouse, 31076 Toulouse Cedex, France.
Present address is Department of Small Animal Surgery, National Veterinary School of Lyon, Marcy l'Etoile, France.

Search for other papers by Guillaume P. Chanoit in
Current site
Google Scholar
PubMed
Close
 DMV
,
Marc Schneider Vétoquinol, 70204 Lure cedex, France.

Search for other papers by Marc Schneider in
Current site
Google Scholar
PubMed
Close
 DMV
,
Frédérique Woehrlé Vétoquinol, 70204 Lure cedex, France.

Search for other papers by Frédérique Woehrlé in
Current site
Google Scholar
PubMed
Close
 DMV
, and
Hervé P. Lefebvre UMR INRA Physiopathologie et Toxicologie Expérimentales, Ecole Vétérinaire de Toulouse, 31076 Toulouse Cedex, France.

Search for other papers by Hervé P. Lefebvre in
Current site
Google Scholar
PubMed
Close
 DMV, PhD

Abstract

Objective—To study the hemodynamic effects of marbofloxacin (MBF) in isoflurane-anesthetized dogs.

Animals—6 healthy 8-month-old Beagles.

Procedure—Anesthesia was induced with sodium thiopental and maintained with isoflurane. Cardiovascular variables were monitored throughout anesthesia. Marbofloxacin was administered by an IV bolus at 2 mg/kg, followed 10 minutes later by an infusion at a rate of 40 mg/kg/h for 30 minutes (total dose, 20 mg/kg). Plasma MBF concentrations were measured by high-performance liquid chromatography.

Results—The mean peak concentration during MBF infusion was 34.2 ± 6.4 µg/mL. The IV administration of the MBF bolus did not alter any cardiovascular variable in isoflurane-anesthetized dogs. Significant changes were found during infusion when a cumulative dose of 12 mg/kg had been given. The maximal decreases observed at the end of the infusion were 16% in heart rate, 26% in systolic left ventricular pressure, 33% in systolic aortic pressure, 38% in diastolic aortic pressure, 29% in cardiac output, and 12% in QT interval. All dogs recovered rapidly from anesthesia at the end of the experiment.

Conclusions and Clinical Relevance—MBF may safely be used at 2 mg/kg IV in isoflurane-anesthetized dogs, and significant adverse cardiovascular effects are found only when 6 to 8 times the recommended dose is given. (Am J Vet Res 2005;66:2090–2094)

Abstract

Objective—To study the hemodynamic effects of marbofloxacin (MBF) in isoflurane-anesthetized dogs.

Animals—6 healthy 8-month-old Beagles.

Procedure—Anesthesia was induced with sodium thiopental and maintained with isoflurane. Cardiovascular variables were monitored throughout anesthesia. Marbofloxacin was administered by an IV bolus at 2 mg/kg, followed 10 minutes later by an infusion at a rate of 40 mg/kg/h for 30 minutes (total dose, 20 mg/kg). Plasma MBF concentrations were measured by high-performance liquid chromatography.

Results—The mean peak concentration during MBF infusion was 34.2 ± 6.4 µg/mL. The IV administration of the MBF bolus did not alter any cardiovascular variable in isoflurane-anesthetized dogs. Significant changes were found during infusion when a cumulative dose of 12 mg/kg had been given. The maximal decreases observed at the end of the infusion were 16% in heart rate, 26% in systolic left ventricular pressure, 33% in systolic aortic pressure, 38% in diastolic aortic pressure, 29% in cardiac output, and 12% in QT interval. All dogs recovered rapidly from anesthesia at the end of the experiment.

Conclusions and Clinical Relevance—MBF may safely be used at 2 mg/kg IV in isoflurane-anesthetized dogs, and significant adverse cardiovascular effects are found only when 6 to 8 times the recommended dose is given. (Am J Vet Res 2005;66:2090–2094)

All Time Past Year Past 30 Days
Abstract Views 38 0 0
Full Text Views 912 807 219
PDF Downloads 143 83 3
Advertisement