Advertisement

Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis

Luc R. BorerNovartis Centre de Recherche, Sante Animale SA, 1566 St-Aubin, Switzerland.

Search for other papers by Luc R. Borer in
Current site
Google Scholar
PubMed
Close
 Dr med vet
,
John E. PeelNovartis Centre de Recherche, Sante Animale SA, 1566 St-Aubin, Switzerland.

Search for other papers by John E. Peel in
Current site
Google Scholar
PubMed
Close
 BVSc
,
Wolfgang SeewaldNovartis Pharma AG, WSJ-386.5.09, 4002 Basel, Switzerland.

Search for other papers by Wolfgang Seewald in
Current site
Google Scholar
PubMed
Close
 Dr sc math
,
Peter SchawalderDivision of Small Animal Surgery and Orthopedics, Faculty of Veterinary Medicine, University of Bern, Switzerland.

Search for other papers by Peter Schawalder in
Current site
Google Scholar
PubMed
Close
 Dr med vet
, and
David E. SprengDivision of Small Animal Surgery and Orthopedics, Faculty of Veterinary Medicine, University of Bern, Switzerland.

Search for other papers by David E. Spreng in
Current site
Google Scholar
PubMed
Close
 PD, Dr med vet

Abstract

Objective—To compare the analgesic and anti-inflammatory effect of single doses of carprofen, etodolac, meloxicam, and butorphanol in dogs with induced acute synovitis (acute pain model) via kinetic gait analysis and orthopedic evaluation and examine measurement of serum C-reactive protein (CRP) concentration as an indicator of treatment efficacy.

Animals—12 Beagles and 6 additional Beagles that were used only in serum CRP analyses.

Procedure—Acute synovitis was induced in right stifle joints of dogs via intra-articular injection of monosodium urate solution. Treatments included butorphanol (0.2 mg/kg, IV), carprofen (4 mg/kg, PO), etodolac (17 mg/kg, PO), or meloxicam (0.2 mg/kg, PO); control dogs received no treatment. The procedure was repeated (3-week intervals) until all dogs received all treatments including control treatment. Lameness was assessed on a biomechanical force platform and via orthopedic evaluations of the stifle joints; blood was collected to monitor serum CRP concentration.

Results—Compared with control dogs, treated dogs had significantly different vertical ground reaction forces and weight-bearing scores. Greatest improvement in lameness was observed in carprofen-treated dogs. Etodolac had the fastest onset of action. Compared with butorphanol treatment, only carprofen and etodolac were associated with significantly lower pain scores. An increase in serum CRP concentration was detected after intra-articular injection in all dogs; this change was similar among groups.

Conclusions and Clinical Relevance—Carprofen, etodolac, and meloxicam had greater efficacy than butorphanol in relief of acute pain. Carprofen was most effective overall. In this acute pain model, serum CRP analysis was not useful to assess drug efficacy. (Am J Vet Res 2003;64:1429–1437)

Abstract

Objective—To compare the analgesic and anti-inflammatory effect of single doses of carprofen, etodolac, meloxicam, and butorphanol in dogs with induced acute synovitis (acute pain model) via kinetic gait analysis and orthopedic evaluation and examine measurement of serum C-reactive protein (CRP) concentration as an indicator of treatment efficacy.

Animals—12 Beagles and 6 additional Beagles that were used only in serum CRP analyses.

Procedure—Acute synovitis was induced in right stifle joints of dogs via intra-articular injection of monosodium urate solution. Treatments included butorphanol (0.2 mg/kg, IV), carprofen (4 mg/kg, PO), etodolac (17 mg/kg, PO), or meloxicam (0.2 mg/kg, PO); control dogs received no treatment. The procedure was repeated (3-week intervals) until all dogs received all treatments including control treatment. Lameness was assessed on a biomechanical force platform and via orthopedic evaluations of the stifle joints; blood was collected to monitor serum CRP concentration.

Results—Compared with control dogs, treated dogs had significantly different vertical ground reaction forces and weight-bearing scores. Greatest improvement in lameness was observed in carprofen-treated dogs. Etodolac had the fastest onset of action. Compared with butorphanol treatment, only carprofen and etodolac were associated with significantly lower pain scores. An increase in serum CRP concentration was detected after intra-articular injection in all dogs; this change was similar among groups.

Conclusions and Clinical Relevance—Carprofen, etodolac, and meloxicam had greater efficacy than butorphanol in relief of acute pain. Carprofen was most effective overall. In this acute pain model, serum CRP analysis was not useful to assess drug efficacy. (Am J Vet Res 2003;64:1429–1437)