Hematologic and serum biochemical changes in Salmonella ser Typhimurium-infected calves

Renato L. Santos Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467.

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Renée M. Tsolis Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843-1114.

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Andreas J. Bäumler Department of Medical Microbiology and Immunology, College of Medicine, Texas A&M University Health Science Center, College Station, TX 77843-1114.

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L. Garry Adams Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467.

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Abstract

Objective—To evaluate hematologic and serum biochemical changes in Salmonella ser Typhimurium infected calves.

Animals—16 male 3- to 4-week-old dairy calves.

Procedure—13 calves were experimentally infected with S Typhimurium (strains IR715 and CS401, which are derivatives of ATCC 14028), and 3 calves were uninfected controls. Several hematologic and serum biochemical parameters were measured.

Results—Hematologic changes included increases in PCV, RBC count, and hemoglobin concentration, associated with a transitory leukopenia characterized by neutropenia and lymphopenia. Biochemical findings included hypoglycemia, increased BUN, creatinine, and fibrinogen concentrations, and decreased sodium, total CO2, calcium, total protein, and albumin concentrations. Increased total bilirubin concentration associated with decreased conjugated bilirubin concentration was also observed. No significant changes in aspartate aminotransferase, γ-glutamyltranspeptidase, alkaline phosphatase, and creatinine kinase activities were detecte

Conclusions and Clinical Relevance—Experimental salmonellosis of calves results in marked to severe dehydration, accompanied by metabolic acidosis, hypoglycemia, and an acute inflammatory response associated with increased fibrinogen concentrations and severe neutropenia immediately after inoculation. (Am J Vet Res 2002;63:1145–1150)

Abstract

Objective—To evaluate hematologic and serum biochemical changes in Salmonella ser Typhimurium infected calves.

Animals—16 male 3- to 4-week-old dairy calves.

Procedure—13 calves were experimentally infected with S Typhimurium (strains IR715 and CS401, which are derivatives of ATCC 14028), and 3 calves were uninfected controls. Several hematologic and serum biochemical parameters were measured.

Results—Hematologic changes included increases in PCV, RBC count, and hemoglobin concentration, associated with a transitory leukopenia characterized by neutropenia and lymphopenia. Biochemical findings included hypoglycemia, increased BUN, creatinine, and fibrinogen concentrations, and decreased sodium, total CO2, calcium, total protein, and albumin concentrations. Increased total bilirubin concentration associated with decreased conjugated bilirubin concentration was also observed. No significant changes in aspartate aminotransferase, γ-glutamyltranspeptidase, alkaline phosphatase, and creatinine kinase activities were detecte

Conclusions and Clinical Relevance—Experimental salmonellosis of calves results in marked to severe dehydration, accompanied by metabolic acidosis, hypoglycemia, and an acute inflammatory response associated with increased fibrinogen concentrations and severe neutropenia immediately after inoculation. (Am J Vet Res 2002;63:1145–1150)

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