Multiple-center study of reduced-concentration triamcinolone topical solution for the treatment of dogs with known or suspected allergic pruritus

Douglas J. DeBoerDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.

Search for other papers by Douglas J. DeBoer in
Current site
Google Scholar
PubMed
Close
 DVM
,
James H. SchaferSchafer Veterinary Consultants, 800 Helena Ct, Ft Collins, CO 80524.

Search for other papers by James H. Schafer in
Current site
Google Scholar
PubMed
Close
 DVM
,
Charles S. SalsburySchafer Veterinary Consultants, 800 Helena Ct, Ft Collins, CO 80524.

Search for other papers by Charles S. Salsbury in
Current site
Google Scholar
PubMed
Close
 MS
,
Jenifer R. BlumDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.

Search for other papers by Jenifer R. Blum in
Current site
Google Scholar
PubMed
Close
 BS
,
Karin M. BealeGulf Coast Veterinary Dermatology and Allergy, 1111 W Loop South, Ste 120, Houston, TX 77027.

Search for other papers by Karin M. Beale in
Current site
Google Scholar
PubMed
Close
 DVM
,
Carlo B. VitaleSan Francisco Veterinary Specialists, 3619 California St, San Francisco, CA 94118.

Search for other papers by Carlo B. Vitale in
Current site
Google Scholar
PubMed
Close
 DVM
,
Russell MuseAnimal Dermatology Clinic, 2965 Edinger Ave, Tustin, CA 92780.

Search for other papers by Russell Muse in
Current site
Google Scholar
PubMed
Close
 DVM
,
Karen A. MorielloDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.

Search for other papers by Karen A. Moriello in
Current site
Google Scholar
PubMed
Close
 DVM
,
Reid A. GarfieldAnimal Dermatology Referral Clinic, 4444 Trinity Mills Rd, No. 101, Dallas, TX 75287.

Search for other papers by Reid A. Garfield in
Current site
Google Scholar
PubMed
Close
 DVM
,
Thomas J. KeefeDepartment of Environmental Health, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Ft Collins, CO 80523.

Search for other papers by Thomas J. Keefe in
Current site
Google Scholar
PubMed
Close
 PhD
, and
T. Reid McArthurRMS Laboratories, 1313 Hwy 280 East, Vidalia, GA 30474.

Search for other papers by T. Reid McArthur in
Current site
Google Scholar
PubMed
Close
 DVM

Abstract

Objective—To determine the efficacy of triamcinolone acetonide topical solution (TTS) in dogs for use in reduction of clinical signs of pruritic inflammatory skin diseases of a known or suspected allergic basis and to evaluate adverse effects associated with TTS administration.

Animals—103 pruritic adult dogs with known or suspected allergic skin disease.

Procedure—Dogs were treated for 4 weeks with TTS or with vehicle solution (control dogs) in a multiplecenter study. Clinical signs were scored by owners and by examining veterinarians before and after treatment. Blood samples obtained before and after treatment were subjected to routine hematologic and serum biochemical analyses.

Results—Treatment success, as defined by an improvement of at least 2 of 6 grades in overall clinical score, was evident in 35 of 52 (67%) TTStreated dogs (mean improvement, 1.98) and 12 of 51 (24%) control dogs (mean improvement, 0.29). For several criteria, TTS was significantly more effective than vehicle in reducing clinical signs. Minor alterations in hematologic determinations in TTS-treated dogs were limited to slightly lower total leukocyte, lymphocyte, and eosinophil counts after treatment. Minor adverse effects were reported by owners in 6 of 52 (12%) TTS-treated and 9 of 51 (18%) control dogs.

Conclusions and Clinical Relevance—Triamcinolone used as a spray solution at a concentration approximately one-sixth the concentration of triamcinolone topical preparations currently available for veterinary use is effective for short-term alleviation of allergic pruritus in dogs. Adverse effects are few and mild and, thus, do not preclude prolonged treatment with the solution. (Am J Vet Res 2002;63:408–413)

Abstract

Objective—To determine the efficacy of triamcinolone acetonide topical solution (TTS) in dogs for use in reduction of clinical signs of pruritic inflammatory skin diseases of a known or suspected allergic basis and to evaluate adverse effects associated with TTS administration.

Animals—103 pruritic adult dogs with known or suspected allergic skin disease.

Procedure—Dogs were treated for 4 weeks with TTS or with vehicle solution (control dogs) in a multiplecenter study. Clinical signs were scored by owners and by examining veterinarians before and after treatment. Blood samples obtained before and after treatment were subjected to routine hematologic and serum biochemical analyses.

Results—Treatment success, as defined by an improvement of at least 2 of 6 grades in overall clinical score, was evident in 35 of 52 (67%) TTStreated dogs (mean improvement, 1.98) and 12 of 51 (24%) control dogs (mean improvement, 0.29). For several criteria, TTS was significantly more effective than vehicle in reducing clinical signs. Minor alterations in hematologic determinations in TTS-treated dogs were limited to slightly lower total leukocyte, lymphocyte, and eosinophil counts after treatment. Minor adverse effects were reported by owners in 6 of 52 (12%) TTS-treated and 9 of 51 (18%) control dogs.

Conclusions and Clinical Relevance—Triamcinolone used as a spray solution at a concentration approximately one-sixth the concentration of triamcinolone topical preparations currently available for veterinary use is effective for short-term alleviation of allergic pruritus in dogs. Adverse effects are few and mild and, thus, do not preclude prolonged treatment with the solution. (Am J Vet Res 2002;63:408–413)