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Usefulness of dobutamine stress tests for detection of cardiac abnormalities in dogs with experimentally induced early left ventricular dysfunction

Kathleen Mc EnteeDepartment of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Cécile ClercxDepartment of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Daniel SoyeurDepartment of Cardiology, Faculty of Medicine, University of Liège, CHU Sart Tilman, 4000 Liège, Belgium.

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Hélène AmoryDepartment of Large Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Charles MichauxDepartment of Genetics, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Thierry FlandreDepartment of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Eva JonvilleDepartment of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Catherine PynnaertDepartment of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Nathalie MiserqueDepartment of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Marc HenroteauxDepartment of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, B44 Sart Tilman, 4000 Liège, Belgium.

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Abstract

Objective—To determine whether dobutamine stress tests (DST) can be used to detect cardiac dysfunction in dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP).

Animals—7 adult male Beagles.

Procedure—A pacemaker was surgically implanted in each dog at the level of the right ventricular apex. Electrocardiography, Doppler sphygmomanometry, and Doppler echocardiography were performed before and during a DST prior to activation of the pacemaker and every 3 to 4 days during the period of RRVP. Dobutamine stress tests were performed by infusing dobutamine at incremental dosages ranging from 12.5 to 42.5 µg/kg of body weight/min.

Results—Clinical signs of congestive heart failure were not observed during the pacing period. However, all dogs developed ELVD associated with significant changes in values for most Doppler echocardiographic variables obtained prior to DST. Adverse cardiac effects were not detected during DST. Most Doppler echocardiographic indices of cardiac function were significantly altered in response to dobutamine infusion during the pacing period, compared with prepacing values. However, a dobutamine-induced 2-fold increase in cardiac output was maintained.

Conclusions and Clinical Relevance—Dobutamine stress tests can be safely performed in dogs with experimentally induced ELVD. Dobutamine stress tests may be a sensitive, noninvasive diagnostic method, complementary to standard clinical examinations, for detection of early cardiac dysfunction in dogs asymptomatic for dilated cardiomyopathy. (Am J Vet Res 2001;62:448–455)

Abstract

Objective—To determine whether dobutamine stress tests (DST) can be used to detect cardiac dysfunction in dogs with early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP).

Animals—7 adult male Beagles.

Procedure—A pacemaker was surgically implanted in each dog at the level of the right ventricular apex. Electrocardiography, Doppler sphygmomanometry, and Doppler echocardiography were performed before and during a DST prior to activation of the pacemaker and every 3 to 4 days during the period of RRVP. Dobutamine stress tests were performed by infusing dobutamine at incremental dosages ranging from 12.5 to 42.5 µg/kg of body weight/min.

Results—Clinical signs of congestive heart failure were not observed during the pacing period. However, all dogs developed ELVD associated with significant changes in values for most Doppler echocardiographic variables obtained prior to DST. Adverse cardiac effects were not detected during DST. Most Doppler echocardiographic indices of cardiac function were significantly altered in response to dobutamine infusion during the pacing period, compared with prepacing values. However, a dobutamine-induced 2-fold increase in cardiac output was maintained.

Conclusions and Clinical Relevance—Dobutamine stress tests can be safely performed in dogs with experimentally induced ELVD. Dobutamine stress tests may be a sensitive, noninvasive diagnostic method, complementary to standard clinical examinations, for detection of early cardiac dysfunction in dogs asymptomatic for dilated cardiomyopathy. (Am J Vet Res 2001;62:448–455)