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Effects of an extract of Serenoa repens on dogs with hyperplasia of the prostate gland

Jeanne A. BarsantiDepartments of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.
Departments of Pharmacology and Physiology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

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Delmar R. FincoDepartments of Pharmacology and Physiology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

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Mary M. MahaffeyDepartments of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

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Richard A. Fayrer-HoskenDepartment of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

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Wayne A. CrowellDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

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Frederick N. Thompson JrDepartments of Pharmacology and Physiology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.

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Emmett B. ShottsDepartments of Medical Microbiology and Parasitology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602.
present address is 1700 Leetown Rd, The National Fish Health Research Laboratory, Kearneysville, WV 25430.

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Abstract

Objective—To determine effects of an extract of Serenoa repens on dogs with prostatic hyperplasia.

Animals—20 mature male dogs with benign prostatic hyperplasia.

Procedure—Dogs were assigned to 3 comparable groups on the basis of prostatic volume per kg of body weight and degree of prostatic hyperplasia determined histologically. Dogs in 2 groups were treated for 91 days (8 received 500 mg, PO, q 8 h [1,500 mg/d], and 6 received 100 mg, PO, q 8 h [300 mg/d]). The control group of 6 dogs did not receive medication. Effects of treatment on prostatic volume, prostatic weight, prostatic histologic characteristics, radiographic and ultrasonographic assessment of prostatic size, results of CBC, serum biochemical analyses, and urinalysis, serum testosterone concentration, and semen characteristics were determined. At the termination of the study, all dogs were euthanatized, and necropsies were performed. Investigators conducting tests and interpreting results were not aware of treatment group of each dog.

Results—Treatment did not affect prostatic weight, prostatic volume, or prostatic histologic scores, libido, semen characteristics, radiographs of the caudal portion of the abdomen, prostatic ultrasonographs, or serum testosterone concentrations. Results of CBC, serum biochemical analyses or urinalysis, and body weights did not change during treatment.

Conclusions and Clinical Relevance—Treatment with an extract of S repens for 91 days did not significantly affect the prostate gland of dogs. Adverse effects were not evident. Although products containing extracts of S repens are widely advertised for men with prostatic hyperplasia, beneficial or harmful effects of this plant extract were not found in dogs with prostatic hyperplasia. (Am J Vet Res 2000;61:880–885)

Abstract

Objective—To determine effects of an extract of Serenoa repens on dogs with prostatic hyperplasia.

Animals—20 mature male dogs with benign prostatic hyperplasia.

Procedure—Dogs were assigned to 3 comparable groups on the basis of prostatic volume per kg of body weight and degree of prostatic hyperplasia determined histologically. Dogs in 2 groups were treated for 91 days (8 received 500 mg, PO, q 8 h [1,500 mg/d], and 6 received 100 mg, PO, q 8 h [300 mg/d]). The control group of 6 dogs did not receive medication. Effects of treatment on prostatic volume, prostatic weight, prostatic histologic characteristics, radiographic and ultrasonographic assessment of prostatic size, results of CBC, serum biochemical analyses, and urinalysis, serum testosterone concentration, and semen characteristics were determined. At the termination of the study, all dogs were euthanatized, and necropsies were performed. Investigators conducting tests and interpreting results were not aware of treatment group of each dog.

Results—Treatment did not affect prostatic weight, prostatic volume, or prostatic histologic scores, libido, semen characteristics, radiographs of the caudal portion of the abdomen, prostatic ultrasonographs, or serum testosterone concentrations. Results of CBC, serum biochemical analyses or urinalysis, and body weights did not change during treatment.

Conclusions and Clinical Relevance—Treatment with an extract of S repens for 91 days did not significantly affect the prostate gland of dogs. Adverse effects were not evident. Although products containing extracts of S repens are widely advertised for men with prostatic hyperplasia, beneficial or harmful effects of this plant extract were not found in dogs with prostatic hyperplasia. (Am J Vet Res 2000;61:880–885)