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Quantitative urinalysis in healthy Beagle puppies from 9 to 27 weeks of age

India F. Lane DVM, MS1,2, Darcy H. Shaw DVM, MVSc3, Shelley A. Burton DVM, MSc4, and Alan W. Donald PhD5,6
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  • 1 Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI C1A 4P3, Canada.
  • | 2 present address is the Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN 37901-1071.
  • | 3 Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI C1A 4P3, Canada.
  • | 4 Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI C1A 4P3, Canada.
  • | 5 Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PEI C1A 4P3, Canada.
  • | 6 present address is 5805 Balsam St, No. 101, Vancouver, BC V6M 4B8, Canada.

Abstract

Objectives—To evaluate indices of renal function in healthy, growing Beagle puppies from 9 to 27 weeks of age and to determine whether indices change with age during this period.

Animals—6 healthy Beagle puppies.

Procedure—Urine collections were performed at 2-week intervals in puppies 9 to 27 weeks old. Daily excretion of urinary creatinine, protein, sodium, potassium, chloride, phosphorus, and calcium were determined, as were quantitative urinalyses including endogenous creatinine clearance, urine protein-tocreatinine ratios (UPr/C), and fractional clearances of sodium (FNa), potassium (FK), chloride (FCl), calcium (FCa), and phosphorus (FP).

Results—Significant differences among age groups were detected for endogenous creatinine clearance, and daily urinary protein, potassium, calcium, and phosphorus excretion. Significant differences also existed among age groups for UPr/C, FNa, FK, FCl and FP. Age-related effects fit a linear regression model for FNa, UPr/C, daily phosphorus excretion, and daily protein excretion. Quadratic regression models were judged most appropriate for endogenous creatinine clearance, FK, daily chloride excretion, and daily potassium excretion. Endogenous creatinine clearance measurements higher than adult reference ranges were observed from 9 to 21 weeks of age. The FNa, FK, FCl, FCa, and FP were slightly higher than those reported for adult dogs.

Conclusions and Clinical Relevance—Selected results of quantitative urinalyses in healthy 9- to 27-week-old Beagle puppies differ with age and differ from those measured in adult dogs. Diagnostic measurements performed in puppies of this age range should be compared with age-matched results when possible. (Am J Vet Res 2000;61:577–581)

Abstract

Objectives—To evaluate indices of renal function in healthy, growing Beagle puppies from 9 to 27 weeks of age and to determine whether indices change with age during this period.

Animals—6 healthy Beagle puppies.

Procedure—Urine collections were performed at 2-week intervals in puppies 9 to 27 weeks old. Daily excretion of urinary creatinine, protein, sodium, potassium, chloride, phosphorus, and calcium were determined, as were quantitative urinalyses including endogenous creatinine clearance, urine protein-tocreatinine ratios (UPr/C), and fractional clearances of sodium (FNa), potassium (FK), chloride (FCl), calcium (FCa), and phosphorus (FP).

Results—Significant differences among age groups were detected for endogenous creatinine clearance, and daily urinary protein, potassium, calcium, and phosphorus excretion. Significant differences also existed among age groups for UPr/C, FNa, FK, FCl and FP. Age-related effects fit a linear regression model for FNa, UPr/C, daily phosphorus excretion, and daily protein excretion. Quadratic regression models were judged most appropriate for endogenous creatinine clearance, FK, daily chloride excretion, and daily potassium excretion. Endogenous creatinine clearance measurements higher than adult reference ranges were observed from 9 to 21 weeks of age. The FNa, FK, FCl, FCa, and FP were slightly higher than those reported for adult dogs.

Conclusions and Clinical Relevance—Selected results of quantitative urinalyses in healthy 9- to 27-week-old Beagle puppies differ with age and differ from those measured in adult dogs. Diagnostic measurements performed in puppies of this age range should be compared with age-matched results when possible. (Am J Vet Res 2000;61:577–581)