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Evaluation of the safety of fenbendazole in cats

Roger D. SchwartzHoechst Roussel Vet, Perryville Corporate Park, PO Box 4010, Clinton, NJ 08809-4010.
present address is Clinical Poultry Research Specialist, 50 Carolee Ln, Bangor, PA 18013.

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Ann R. DonoghueHoechst Roussel Vet, Perryville Corporate Park, PO Box 4010, Clinton, NJ 08809-4010.
present address is Heska Corporation, 1613 Prospect Pkwy, Fort Collins, CO 80525.

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Raymond B. BaggsDivision of Lab Animal Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642.

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Theodore ClarkLiberty Research Inc, PO Box 107, Rte 17C, Waverly, NY 14892-0107.
present address is 718 W Main St, Bellevue, OH 44811.

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Carol PartingtonLiberty Research Inc, PO Box 107, Rte 17C, Waverly, NY 14892-0107.
present address is 222B Bailey-Waters Rd, Dawsonville, GA 30534.

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Abstract

Objective—To evaluate the safety of fenbendazole in domestic cats.

Animals—28 six- to seven-month old domestic shorthair cats.

Procedure—Cats were randomly assigned to 1 of 3 treatment groups or a control group (n = 7/group). Cats in the treatment groups were given fenbendazole at a dosage of 50, 150, or 250 mg/kg, PO, every 24 hours for 9 days; control cats were given a placebo. A fecal examination, coagulation tests, serum biochemical analyses, CBC, and urinalyses were performed before and 5, 9, and 21 days after initiation of treatment; cats were closely monitored for adverse reactions. After the last dose of fenbendazole was given, 4 control cats and 4 cats given fenbendazole at the highest dosage were euthanatized, and necropsies were performed.

Results—None of the cats developed any adverse reactions. For cats in the control and all treated groups, laboratory test results were within reference limits, and there were no significant differences in results of laboratory tests among groups. No gross or histologic lesions were identified in the control or treated cats that were euthanatized.

Conclusions and Clinical Relevance—Fenbendazole administered to healthy cats at a dosage 5 times the dosage and 3 times the duration approved for use in dogs and wild felids did not cause any acute or subacute adverse reactions or pathologic changes. Results suggest that cats may be safely treated with fenbendazole. (Am J Vet Res 2000;61:330–332)

Abstract

Objective—To evaluate the safety of fenbendazole in domestic cats.

Animals—28 six- to seven-month old domestic shorthair cats.

Procedure—Cats were randomly assigned to 1 of 3 treatment groups or a control group (n = 7/group). Cats in the treatment groups were given fenbendazole at a dosage of 50, 150, or 250 mg/kg, PO, every 24 hours for 9 days; control cats were given a placebo. A fecal examination, coagulation tests, serum biochemical analyses, CBC, and urinalyses were performed before and 5, 9, and 21 days after initiation of treatment; cats were closely monitored for adverse reactions. After the last dose of fenbendazole was given, 4 control cats and 4 cats given fenbendazole at the highest dosage were euthanatized, and necropsies were performed.

Results—None of the cats developed any adverse reactions. For cats in the control and all treated groups, laboratory test results were within reference limits, and there were no significant differences in results of laboratory tests among groups. No gross or histologic lesions were identified in the control or treated cats that were euthanatized.

Conclusions and Clinical Relevance—Fenbendazole administered to healthy cats at a dosage 5 times the dosage and 3 times the duration approved for use in dogs and wild felids did not cause any acute or subacute adverse reactions or pathologic changes. Results suggest that cats may be safely treated with fenbendazole. (Am J Vet Res 2000;61:330–332)