Pulmonary distribution of aerosolized technetium Tc 99m pentetate after administration of a single dose of aerosolized albuterol sulfate in horses with recurrent airway obstruction

Bonnie R. Rush From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606 (Rush, Hoskinson, Davis) and 3M Animal Care Products, 3M Center, Bldg 270-3S-05, Conway Dr. St Paul, MN 55144-1000 (Matson, Hakala).

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James J. Hoskinson From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606 (Rush, Hoskinson, Davis) and 3M Animal Care Products, 3M Center, Bldg 270-3S-05, Conway Dr. St Paul, MN 55144-1000 (Matson, Hakala).

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Elizabeth G. Davis From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606 (Rush, Hoskinson, Davis) and 3M Animal Care Products, 3M Center, Bldg 270-3S-05, Conway Dr. St Paul, MN 55144-1000 (Matson, Hakala).

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Charles J. Matson From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606 (Rush, Hoskinson, Davis) and 3M Animal Care Products, 3M Center, Bldg 270-3S-05, Conway Dr. St Paul, MN 55144-1000 (Matson, Hakala).

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Joyce E. Hakala From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606 (Rush, Hoskinson, Davis) and 3M Animal Care Products, 3M Center, Bldg 270-3S-05, Conway Dr. St Paul, MN 55144-1000 (Matson, Hakala).

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Abstract

Objective

To determine whether pulmonary distribution of aerosolized technetium Tc 99m pentetate is improved after inhalation of a single dose of albuterol sulfate in horses susceptible to recurrent airway obstruction (heaves).

Animals

6 horses with heaves and 4 horses with normal respiratory tract function.

Procedure

Images were obtained during ventilation of horses at baseline (maximal change in pleural pressure during tidal breathing [ΔPplmax] > 15 cm H2O) and after aerosolized albuterol sulfate (360 µg) administration, with a 24-hour washout period between experiments. The ΔPplmax was determined prior to the baseline scan, prior to albuterol sulfate administration, and 5 minutes after albuterol sulfate administration. Images were assessed by visual inspection (semiquantitative scoring system) and histogram analysis.

Results

Images obtained from horses with heaves had nonuniform pulmonary distribution of radionuclide characterized by poor penetration in peripheral lung fields and excess deposition in large airways. Histogram analysis of images of the caudal portions of the lungs revealed nonuniform radionuclide deposition in horses with heaves and uniform radionuclide deposition in control horses.

Conclusion

Administration of a single dose of aerosolized albuterol sulfate improved pulmonary distribution of aerosolized radiolabeled pentetate suspension in horses with heaves but did not alter pulmonary distribution in clinically normal horses.

Clinical Relevance

Precedent bronchodilator administration may improve pulmonary distribution of aerosolized, surface-active anti-inflammatory preparations. (Am J Vet Res 1999;60:764–769)

Abstract

Objective

To determine whether pulmonary distribution of aerosolized technetium Tc 99m pentetate is improved after inhalation of a single dose of albuterol sulfate in horses susceptible to recurrent airway obstruction (heaves).

Animals

6 horses with heaves and 4 horses with normal respiratory tract function.

Procedure

Images were obtained during ventilation of horses at baseline (maximal change in pleural pressure during tidal breathing [ΔPplmax] > 15 cm H2O) and after aerosolized albuterol sulfate (360 µg) administration, with a 24-hour washout period between experiments. The ΔPplmax was determined prior to the baseline scan, prior to albuterol sulfate administration, and 5 minutes after albuterol sulfate administration. Images were assessed by visual inspection (semiquantitative scoring system) and histogram analysis.

Results

Images obtained from horses with heaves had nonuniform pulmonary distribution of radionuclide characterized by poor penetration in peripheral lung fields and excess deposition in large airways. Histogram analysis of images of the caudal portions of the lungs revealed nonuniform radionuclide deposition in horses with heaves and uniform radionuclide deposition in control horses.

Conclusion

Administration of a single dose of aerosolized albuterol sulfate improved pulmonary distribution of aerosolized radiolabeled pentetate suspension in horses with heaves but did not alter pulmonary distribution in clinically normal horses.

Clinical Relevance

Precedent bronchodilator administration may improve pulmonary distribution of aerosolized, surface-active anti-inflammatory preparations. (Am J Vet Res 1999;60:764–769)

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