Efficacy of a pour-on formulation of doramectin against lice, mites, and grubs of cattle

Kathleen A. Rooney From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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E. F. Illyes From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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S. J. Sunderland From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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P. Sarasola From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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M. O. Hendrickx From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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D. S. Keller From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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T. R. Meinert From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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N. B. Logan From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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A. J. Weatherley From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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G. A. Conder From Pfizer Central Research, Groton, CT 06340 (Rooney, Illyes, Keller, Meinert, Logan, Conder) and Pfizer Central Research, Sandwich, CT13 9NJ, United Kingdom (Sunderland, Sarasola, Hendrickx, Weatherley)

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Abstract

Objective

To determine effectiveness of a pour-on formulation of doramectin against Damalinia bovis, Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus, Chorioptes bovis, Sarcoptes scabiei, Hypoderma bovis, and Hypoderma lineatum.

Animals

Cattle of various ages with naturally acquired or artificial infestations with 1 or more species of lice, mites, or grubs.

Procedure

In 10 louse and 6 mite studies, cattle were treated with doramectin (500 µg/kg, topically) on day 0, and parasite counts were performed approximately weekly from days 0 to 35. In 6 grub studies, cattle expected to harbor Hypoderma spp were treated before emergence of warbles. After warbles began to emerge, they were counted every 2 weeks, and grubs were collected and identified by species.

Results

Burdens of D bovis, H eurysternus, L vituli, and S capillatus on doramectin-treated cattle were 0 by 28 days after treatment. Burdens of C bovis and S scabiei decreased to 0 in naturally infested cattle and approximately 0 in artificially infested cattle by day 14 to 15. In grub studies, 107 of 136 control cattle had warbles, whereas 2 of 136 doramectin-treated cattle had 1 warble each, which represented a cure rate of 98.5%.

Conclusion and Clinical Relevance

One topical application of doramectin was highly efficacious against common species of lice, mites, and grubs known to affect performance, health, and appearance of cattle. (Am J Vet Res 1999;60:402-404)

Abstract

Objective

To determine effectiveness of a pour-on formulation of doramectin against Damalinia bovis, Haematopinus eurysternus, Linognathus vituli, Solenopotes capillatus, Chorioptes bovis, Sarcoptes scabiei, Hypoderma bovis, and Hypoderma lineatum.

Animals

Cattle of various ages with naturally acquired or artificial infestations with 1 or more species of lice, mites, or grubs.

Procedure

In 10 louse and 6 mite studies, cattle were treated with doramectin (500 µg/kg, topically) on day 0, and parasite counts were performed approximately weekly from days 0 to 35. In 6 grub studies, cattle expected to harbor Hypoderma spp were treated before emergence of warbles. After warbles began to emerge, they were counted every 2 weeks, and grubs were collected and identified by species.

Results

Burdens of D bovis, H eurysternus, L vituli, and S capillatus on doramectin-treated cattle were 0 by 28 days after treatment. Burdens of C bovis and S scabiei decreased to 0 in naturally infested cattle and approximately 0 in artificially infested cattle by day 14 to 15. In grub studies, 107 of 136 control cattle had warbles, whereas 2 of 136 doramectin-treated cattle had 1 warble each, which represented a cure rate of 98.5%.

Conclusion and Clinical Relevance

One topical application of doramectin was highly efficacious against common species of lice, mites, and grubs known to affect performance, health, and appearance of cattle. (Am J Vet Res 1999;60:402-404)

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