Dose titration of an injectable formulation of lufenuron in cats experimentally infested with fleas

Byron L. Blagburn From the Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 (Blagburn, Vaughan, Butler); and Novartis Animal Health, 3200 Northline Ave, Ste 300, Greensboro, NC 27419 (Parks).

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Joy L. Vaughan From the Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 (Blagburn, Vaughan, Butler); and Novartis Animal Health, 3200 Northline Ave, Ste 300, Greensboro, NC 27419 (Parks).

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Jamie M. Butler From the Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 (Blagburn, Vaughan, Butler); and Novartis Animal Health, 3200 Northline Ave, Ste 300, Greensboro, NC 27419 (Parks).

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S. Craig Parks From the Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849 (Blagburn, Vaughan, Butler); and Novartis Animal Health, 3200 Northline Ave, Ste 300, Greensboro, NC 27419 (Parks).

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Abstract

Objectives

To identify the lowest single dose of lufenuron injected SC that results in a 90% disruption of the flea (Ctenocephalides felis) life cycle for 6 months in cats.

Animals

40 domestic shorthair cats (20 males, 20 females) between 5 and 7 months old.

Procedure

Cats were randomly assigned to 1 of 5 eight-cat groups and experimentally infested with C felis on days −8, −7, −6, and −4. On day 0, cats in the 4 treatment groups were treated with an injectable formulation of lufenuron at doses of 2.5, 5, 10, or 20 mg/kg of body weight, respectively. Control cats received the injectable formulation without lufenuron. Experimental infestations were repeated and flea eggs collected at various intervals for 196 days after treatment. Eggs were placed in media and incubated in an insectary for 28 days to determine effects of injectable lufenuron on egg and larval development. Number of adults that emerged from eggs were compared among groups.

Results

Lufenuron injected once at a dose of 10 or 20 mg/kg, but not at 2.5 or 5 mg/kg, resulted in a 90% decrease in number of adult fleas emerging from eggs for 196 days after treatment.

Conclusions and Clinical Relevance

Results indicate that control of flea egg and larval development for at least 6 months can be achieved in cats with a single SC injection of lufenuron (10 mg/kg). The injectable formulation may provide veterinarians and cat owners an alternative to the tablet formulation of lufenuron. (Am J Vet Res 1999;60:1513–1515)

Abstract

Objectives

To identify the lowest single dose of lufenuron injected SC that results in a 90% disruption of the flea (Ctenocephalides felis) life cycle for 6 months in cats.

Animals

40 domestic shorthair cats (20 males, 20 females) between 5 and 7 months old.

Procedure

Cats were randomly assigned to 1 of 5 eight-cat groups and experimentally infested with C felis on days −8, −7, −6, and −4. On day 0, cats in the 4 treatment groups were treated with an injectable formulation of lufenuron at doses of 2.5, 5, 10, or 20 mg/kg of body weight, respectively. Control cats received the injectable formulation without lufenuron. Experimental infestations were repeated and flea eggs collected at various intervals for 196 days after treatment. Eggs were placed in media and incubated in an insectary for 28 days to determine effects of injectable lufenuron on egg and larval development. Number of adults that emerged from eggs were compared among groups.

Results

Lufenuron injected once at a dose of 10 or 20 mg/kg, but not at 2.5 or 5 mg/kg, resulted in a 90% decrease in number of adult fleas emerging from eggs for 196 days after treatment.

Conclusions and Clinical Relevance

Results indicate that control of flea egg and larval development for at least 6 months can be achieved in cats with a single SC injection of lufenuron (10 mg/kg). The injectable formulation may provide veterinarians and cat owners an alternative to the tablet formulation of lufenuron. (Am J Vet Res 1999;60:1513–1515)

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