Quantification of left ventricular diastolic wall motion by Doppler tissue imaging in healthy cats and cats with cardiomyopathy

Brad J. Gavaghan From the Department of Medicine and Epidemiology (B. Gavaghan, Kittleson, Fisher) and the Department of Population Health and Reproduction (Kass), School of Veterinary Medicine, University of California, Davis, CA 95616; and 1401 Orchard Park Circle, Davis CA 95616 (M. Gavaghan).

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Mark D. Kittleson From the Department of Medicine and Epidemiology (B. Gavaghan, Kittleson, Fisher) and the Department of Population Health and Reproduction (Kass), School of Veterinary Medicine, University of California, Davis, CA 95616; and 1401 Orchard Park Circle, Davis CA 95616 (M. Gavaghan).

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Kristian J. Fisher From the Department of Medicine and Epidemiology (B. Gavaghan, Kittleson, Fisher) and the Department of Population Health and Reproduction (Kass), School of Veterinary Medicine, University of California, Davis, CA 95616; and 1401 Orchard Park Circle, Davis CA 95616 (M. Gavaghan).

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Philip H. Kass From the Department of Medicine and Epidemiology (B. Gavaghan, Kittleson, Fisher) and the Department of Population Health and Reproduction (Kass), School of Veterinary Medicine, University of California, Davis, CA 95616; and 1401 Orchard Park Circle, Davis CA 95616 (M. Gavaghan).

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Michelle A. Gavaghan From the Department of Medicine and Epidemiology (B. Gavaghan, Kittleson, Fisher) and the Department of Population Health and Reproduction (Kass), School of Veterinary Medicine, University of California, Davis, CA 95616; and 1401 Orchard Park Circle, Davis CA 95616 (M. Gavaghan).

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Abstract

Objective

To assess Doppler tissue imaging (DTI) for evaluating left ventricular diastolic wall motion in healthy cats and cats with cardiomyopathy.

Animals

20 healthy cats, 9 cats with hypertrophic cardiomyopathy (HCM), and 9 cats with unclassified cardiomyopathy (UCM).

Procedure

A pulsed wave DTI sample gate was positioned at a subendocardial region of the left ventricular free wall in the short axis view and at the lateral mitral annulus in the apical 4-chamber view. Indices of diastolic wall motion were measured, including peak diastolic velocity (PDV), mean rate of acceleration and deceleration of the maximal diastolic waveform (MDWaccel and MDWdecel, respectively), and isovolumetric relaxation time (IVRT).

Results

The PDV of cats with HCM and 6 of 9 cats with UCM was significantly decreased, compared with that of healthy cats. In the 3 cats with UCM that had a PDV that was not different from healthy cats, MDWaccel and MDWdecel were greater, and IVRT was shorter than those of healthy cats. The IVRT in cats with HCM was longer than that of other cats.

Conclusions and Clinical Relevance

Indices of diastolic function in cats with HCM, and in many cats with UCM, differed from those of healthy cats and were similar to those reported in humans with HCM and restrictive cardiomyopathy, respectively. However, the hemodynamic abnormality was not the same for all cats with UCM; some cats with an enlarged left atrium and a normal left ventricle (ie, UCM) had abnormal left ventricular wall motion consistent with restrictive cardiomyopathy while others did not. (Am J Vet Res 1999;60:1478–1486)

Abstract

Objective

To assess Doppler tissue imaging (DTI) for evaluating left ventricular diastolic wall motion in healthy cats and cats with cardiomyopathy.

Animals

20 healthy cats, 9 cats with hypertrophic cardiomyopathy (HCM), and 9 cats with unclassified cardiomyopathy (UCM).

Procedure

A pulsed wave DTI sample gate was positioned at a subendocardial region of the left ventricular free wall in the short axis view and at the lateral mitral annulus in the apical 4-chamber view. Indices of diastolic wall motion were measured, including peak diastolic velocity (PDV), mean rate of acceleration and deceleration of the maximal diastolic waveform (MDWaccel and MDWdecel, respectively), and isovolumetric relaxation time (IVRT).

Results

The PDV of cats with HCM and 6 of 9 cats with UCM was significantly decreased, compared with that of healthy cats. In the 3 cats with UCM that had a PDV that was not different from healthy cats, MDWaccel and MDWdecel were greater, and IVRT was shorter than those of healthy cats. The IVRT in cats with HCM was longer than that of other cats.

Conclusions and Clinical Relevance

Indices of diastolic function in cats with HCM, and in many cats with UCM, differed from those of healthy cats and were similar to those reported in humans with HCM and restrictive cardiomyopathy, respectively. However, the hemodynamic abnormality was not the same for all cats with UCM; some cats with an enlarged left atrium and a normal left ventricle (ie, UCM) had abnormal left ventricular wall motion consistent with restrictive cardiomyopathy while others did not. (Am J Vet Res 1999;60:1478–1486)

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