Effects of dexamethasone administration on serum trypsin-like immunoreactivity in healthy dogs

Rosario Lucena From the Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Campus de Rabanales, Ctra Madrid-Cádiz km 396, 14014 Córdoba, Spain.

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Pedro J. Ginel From the Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Campus de Rabanales, Ctra Madrid-Cádiz km 396, 14014 Córdoba, Spain.

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Manuel Novales From the Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Campus de Rabanales, Ctra Madrid-Cádiz km 396, 14014 Córdoba, Spain.

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José M. Molleda From the Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Campus de Rabanales, Ctra Madrid-Cádiz km 396, 14014 Córdoba, Spain.

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Abstract

Objective

To determine whether administration of dexamethasone altered serum trypsin-like immunore-activity (TLI) in healthy dogs.

Animals

12 healthy dogs.

Procedure

Dexamethasone (0.25 mg/kg, PO, q 24 h) was administered for 7 days. Serum TLI, α-amylase and alanine aminotransferase (ALT) activities, and urea and creatinine concentrations were determined on days 0, 7, 14, and 21 of the study.

Results

Serum TLI and ALT activities were significantly increased, and serum α-amylase activity was significantly decreased after administration of dexamethasone for 7 days. However, values obtained on days 14 and 21 were not significantly different from baseline values. Dexamethasone administration was not associated with any significant changes in serum creatinine or urea concentrations. Serum TLI and α-amylase activities were significantly correlated prior to dexamethasone administration. Dogs did not develop clinical signs of pancreatitis.

Conclusions and Clinical Relevance

Dexamethasone administration was associated with an increase in serum TLI. However, values returned to baseline 7 days after dexamethasone administration was discontinued. Serum TLI may be falsely high in dogs that have been treated with dexamethasone in the week preceding analysis. (Am J Vet Res 1999;60:1357–1359)

Abstract

Objective

To determine whether administration of dexamethasone altered serum trypsin-like immunore-activity (TLI) in healthy dogs.

Animals

12 healthy dogs.

Procedure

Dexamethasone (0.25 mg/kg, PO, q 24 h) was administered for 7 days. Serum TLI, α-amylase and alanine aminotransferase (ALT) activities, and urea and creatinine concentrations were determined on days 0, 7, 14, and 21 of the study.

Results

Serum TLI and ALT activities were significantly increased, and serum α-amylase activity was significantly decreased after administration of dexamethasone for 7 days. However, values obtained on days 14 and 21 were not significantly different from baseline values. Dexamethasone administration was not associated with any significant changes in serum creatinine or urea concentrations. Serum TLI and α-amylase activities were significantly correlated prior to dexamethasone administration. Dogs did not develop clinical signs of pancreatitis.

Conclusions and Clinical Relevance

Dexamethasone administration was associated with an increase in serum TLI. However, values returned to baseline 7 days after dexamethasone administration was discontinued. Serum TLI may be falsely high in dogs that have been treated with dexamethasone in the week preceding analysis. (Am J Vet Res 1999;60:1357–1359)

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