Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty

Terrance D. Braden From the Departments of Small Animal Clinical Sciences (Braden, DeCamp) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824; the Department of Orthopedic Surgery, Rush-Presbyterian-St Luke's Medical Center, 2242 W Harrison, Chicago, IL 60612 (Turner); Pharmacia and Upjohn Co, 700 Portage Rd, Kalamazoo, MI 49001 (Hughes); and Biopure Corp, 11 Hurley St, Cambridge, MA 02141 (Rentko).

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Harold W. Tvedten From the Departments of Small Animal Clinical Sciences (Braden, DeCamp) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824; the Department of Orthopedic Surgery, Rush-Presbyterian-St Luke's Medical Center, 2242 W Harrison, Chicago, IL 60612 (Turner); Pharmacia and Upjohn Co, 700 Portage Rd, Kalamazoo, MI 49001 (Hughes); and Biopure Corp, 11 Hurley St, Cambridge, MA 02141 (Rentko).

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Charles E. DeCamp From the Departments of Small Animal Clinical Sciences (Braden, DeCamp) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824; the Department of Orthopedic Surgery, Rush-Presbyterian-St Luke's Medical Center, 2242 W Harrison, Chicago, IL 60612 (Turner); Pharmacia and Upjohn Co, 700 Portage Rd, Kalamazoo, MI 49001 (Hughes); and Biopure Corp, 11 Hurley St, Cambridge, MA 02141 (Rentko).

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Thomas M. Turner From the Departments of Small Animal Clinical Sciences (Braden, DeCamp) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824; the Department of Orthopedic Surgery, Rush-Presbyterian-St Luke's Medical Center, 2242 W Harrison, Chicago, IL 60612 (Turner); Pharmacia and Upjohn Co, 700 Portage Rd, Kalamazoo, MI 49001 (Hughes); and Biopure Corp, 11 Hurley St, Cambridge, MA 02141 (Rentko).

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George S. Hughes From the Departments of Small Animal Clinical Sciences (Braden, DeCamp) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824; the Department of Orthopedic Surgery, Rush-Presbyterian-St Luke's Medical Center, 2242 W Harrison, Chicago, IL 60612 (Turner); Pharmacia and Upjohn Co, 700 Portage Rd, Kalamazoo, MI 49001 (Hughes); and Biopure Corp, 11 Hurley St, Cambridge, MA 02141 (Rentko).

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Virginia T. Rentko From the Departments of Small Animal Clinical Sciences (Braden, DeCamp) and Pathology (Tvedten), College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824; the Department of Orthopedic Surgery, Rush-Presbyterian-St Luke's Medical Center, 2242 W Harrison, Chicago, IL 60612 (Turner); Pharmacia and Upjohn Co, 700 Portage Rd, Kalamazoo, MI 49001 (Hughes); and Biopure Corp, 11 Hurley St, Cambridge, MA 02141 (Rentko).

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Abstract

Objective

To determine whether use of hemoglobin glutamer-200 (bovine) as a partial blood volume replacement in dogs undergoing cemented total hip replacement caused any deleterious effects on the bone-cement or cement-prosthesis interface, exerted any deleterious effects on body organs, or caused any complications during the anesthetic, immediate recovery, or long-term recovery period.

Animals

9 adult dogs.

Methods

Dogs were anesthetized, and 15% of the blood volume was removed. Simultaneously, lactated Ringer's solution was infused, and 6 dogs were given hemoglobin glutamer (1 g/kg of body weight, IV). Unilateral total hip replacement was performed. Limb use was assessed visually, and force-plate and radiographic evaluations were performed before, and 8 weeks after, surgery. Eight weeks after surgery, dogs were euthanatized, necropsies were performed, and prosthetic component pullout forces were determined.

Results

There were no significant differences between treated and control dogs in regard to biomechanical (visual assessment of gait, force-plate analysis, femoral and acetabular component pullout forces) and pathologic evaluations (physical examination, CBC, serum biochemical analyses, necropsy, and histologic evaluations). Radiographic signs of loosening of the femoral component were seen in 4 dogs treated with hemoglobin glutamer.

Conclusions and Clinical Relevance

Administration of hemoglobin glutamer as a blood substitute did not appear to have any deleterious effects in dogs undergoing total hip arthroplasty. The radiographic findings, which were discordant with the biomechanical results, merit further investigation. (Am J Vet Res 1999;60:1337–1340)

Abstract

Objective

To determine whether use of hemoglobin glutamer-200 (bovine) as a partial blood volume replacement in dogs undergoing cemented total hip replacement caused any deleterious effects on the bone-cement or cement-prosthesis interface, exerted any deleterious effects on body organs, or caused any complications during the anesthetic, immediate recovery, or long-term recovery period.

Animals

9 adult dogs.

Methods

Dogs were anesthetized, and 15% of the blood volume was removed. Simultaneously, lactated Ringer's solution was infused, and 6 dogs were given hemoglobin glutamer (1 g/kg of body weight, IV). Unilateral total hip replacement was performed. Limb use was assessed visually, and force-plate and radiographic evaluations were performed before, and 8 weeks after, surgery. Eight weeks after surgery, dogs were euthanatized, necropsies were performed, and prosthetic component pullout forces were determined.

Results

There were no significant differences between treated and control dogs in regard to biomechanical (visual assessment of gait, force-plate analysis, femoral and acetabular component pullout forces) and pathologic evaluations (physical examination, CBC, serum biochemical analyses, necropsy, and histologic evaluations). Radiographic signs of loosening of the femoral component were seen in 4 dogs treated with hemoglobin glutamer.

Conclusions and Clinical Relevance

Administration of hemoglobin glutamer as a blood substitute did not appear to have any deleterious effects in dogs undergoing total hip arthroplasty. The radiographic findings, which were discordant with the biomechanical results, merit further investigation. (Am J Vet Res 1999;60:1337–1340)

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