Physiologic response to dobutamine infusion during cardiac stress testing of dogs

Kathleen McEntee From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Kathleen McEntee in
Current site
Google Scholar
PubMed
Close
 DVM
,
Hélène Amory From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Hélène Amory in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Cécile Clercx From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Cécile Clercx in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Daniel Soyeur From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Daniel Soyeur in
Current site
Google Scholar
PubMed
Close
 MD, PhD
,
Charles Michaux From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Charles Michaux in
Current site
Google Scholar
PubMed
Close
 DVM, PhD
,
Olivier Vanhaeverbeek From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Olivier Vanhaeverbeek in
Current site
Google Scholar
PubMed
Close
 DVM
,
Olivier Jacqmot From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Olivier Jacqmot in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Marc Henroteaux From the Small Animal Clinic, Faculty of Veterinary Medicine, University of Liège, B44, Sart Tilman, 4000 Liège, Belgium.

Search for other papers by Marc Henroteaux in
Current site
Google Scholar
PubMed
Close
 DVM

Click on author name to view affiliation information

Abstract

Objective

To evaluate response of various cardiovascular variables after administration of incremental doses of dobutamine in healthy conscious dogs, using standardized dobutamine stress echocardiography (DSE).

Animals

8 healthy dogs.

Procedure

A DSE was performed twice on each dog within 24 hours. Dobutamine was infused at a rate of 12.5 to 42.5 μg/kg/min, using incremental increases of 10 μg/kg/min. Doppler sphygmomanometry, electrocardiography, and echocardiography were performed. Left ventricular size, global ventricular performance, and left ventricular systolic myocardial function were measured by means of echocardiography.

Results

At the highest dosage, dobutamine induced an increase of 20 ± 3% and 109 ± 12% in systolic blood pressure and cardiac index, respectively. The latter was associated with a significant increase in heart rate and stroke index. Fractional shortening of the left ventricle, fractional thickening of the left ventricular free wall and interventricular septum, ejection fraction, and mean velocity of fiber shortening had a progressive and significant increase during dobutamine infusion. Preejection period and left ventricular ejection time had a progressive and significative decrease during the stress test.

Conclusions

The technique used was feasable, safe, and repeatable in healthy conscious dogs. Control values were determined.

Clinical Relevance

Data for these healthy dogs might be useful for comparison with results obtained from dogs with known or suspected cardiovascular disease. (Am J Vet Res 1998;59:1160-1165)

Abstract

Objective

To evaluate response of various cardiovascular variables after administration of incremental doses of dobutamine in healthy conscious dogs, using standardized dobutamine stress echocardiography (DSE).

Animals

8 healthy dogs.

Procedure

A DSE was performed twice on each dog within 24 hours. Dobutamine was infused at a rate of 12.5 to 42.5 μg/kg/min, using incremental increases of 10 μg/kg/min. Doppler sphygmomanometry, electrocardiography, and echocardiography were performed. Left ventricular size, global ventricular performance, and left ventricular systolic myocardial function were measured by means of echocardiography.

Results

At the highest dosage, dobutamine induced an increase of 20 ± 3% and 109 ± 12% in systolic blood pressure and cardiac index, respectively. The latter was associated with a significant increase in heart rate and stroke index. Fractional shortening of the left ventricle, fractional thickening of the left ventricular free wall and interventricular septum, ejection fraction, and mean velocity of fiber shortening had a progressive and significant increase during dobutamine infusion. Preejection period and left ventricular ejection time had a progressive and significative decrease during the stress test.

Conclusions

The technique used was feasable, safe, and repeatable in healthy conscious dogs. Control values were determined.

Clinical Relevance

Data for these healthy dogs might be useful for comparison with results obtained from dogs with known or suspected cardiovascular disease. (Am J Vet Res 1998;59:1160-1165)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 86 86 32
PDF Downloads 33 33 3
Advertisement