Comparison of radiographic and necropsy findings of lung lesions in calves after challenge exposure with Pasteurella multocida

Gary F. Jones From Biological Research & Development, Bayer Animal Health, 9009 W 67th St, Bldg 8, Merriam, KS 66202-3632 (Jones), the Department of Veterinary Imaging, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108 (Feeney), and the Veterinary Medical Center PA, Worthington, MN 56187 (Mews).

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Daniel A. Feeney From Biological Research & Development, Bayer Animal Health, 9009 W 67th St, Bldg 8, Merriam, KS 66202-3632 (Jones), the Department of Veterinary Imaging, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108 (Feeney), and the Veterinary Medical Center PA, Worthington, MN 56187 (Mews).

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Cindy Mews From Biological Research & Development, Bayer Animal Health, 9009 W 67th St, Bldg 8, Merriam, KS 66202-3632 (Jones), the Department of Veterinary Imaging, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108 (Feeney), and the Veterinary Medical Center PA, Worthington, MN 56187 (Mews).

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Abstract

Objectives

To test suitability of radiographic evaluation of lung lesions as a substitute for lung lesion scores derived by examination at necropsy in challenge-exposure models of bovine pneumonia.

Animals

10 calves selected by body weight from 20 multiple-source male Holstein calves approximately 1 to 2 months old enrolled in a Pasteurella multocida challenge-exposure study.

Procedure

Calves were paired on the basis of weight and randomly assigned within pairs to vaccine or control (saline solution) group. By use of deep tracheal cannulation, calves were challenge exposed with a culture of virulent P multocida, observed for 10 days, euthanatized, and necropsied, and the lungs were scored for pneumonic lesions. Radiographic views of the lung fields of the calves were taken before challenge exposure and before necropsy and were evaluated for alveolar disease by a veterinary radiologist. Lung lesion scores were compared with radiographic evaluations.

Results

There was a strong and significant correlation (R2 = 0.91, P < 0.001) between results of the evaluation of postchallenge-exposure radiographs and necropsy results. There also was also strong and significant correlation (R2 = 0.90, P < 0.001) between evaluation of the prechallenge-exposure radiographs and necropsy results.

Conclusions

Radiographic evaluation of lung lesions correlates well with lung lesions found at necropsy. The findings emphasize the need for caution in interpreting the results of challenge-exposure studies of bovine respiratory tract disease in which small numbers of calves are studied. (Am J Vet Res 1998;59: 1108-1112)

Abstract

Objectives

To test suitability of radiographic evaluation of lung lesions as a substitute for lung lesion scores derived by examination at necropsy in challenge-exposure models of bovine pneumonia.

Animals

10 calves selected by body weight from 20 multiple-source male Holstein calves approximately 1 to 2 months old enrolled in a Pasteurella multocida challenge-exposure study.

Procedure

Calves were paired on the basis of weight and randomly assigned within pairs to vaccine or control (saline solution) group. By use of deep tracheal cannulation, calves were challenge exposed with a culture of virulent P multocida, observed for 10 days, euthanatized, and necropsied, and the lungs were scored for pneumonic lesions. Radiographic views of the lung fields of the calves were taken before challenge exposure and before necropsy and were evaluated for alveolar disease by a veterinary radiologist. Lung lesion scores were compared with radiographic evaluations.

Results

There was a strong and significant correlation (R2 = 0.91, P < 0.001) between results of the evaluation of postchallenge-exposure radiographs and necropsy results. There also was also strong and significant correlation (R2 = 0.90, P < 0.001) between evaluation of the prechallenge-exposure radiographs and necropsy results.

Conclusions

Radiographic evaluation of lung lesions correlates well with lung lesions found at necropsy. The findings emphasize the need for caution in interpreting the results of challenge-exposure studies of bovine respiratory tract disease in which small numbers of calves are studied. (Am J Vet Res 1998;59: 1108-1112)

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