Editorial Type:
Clinical Pathology

Role of the large intestine in the pathogenesis of diarrhea in weaned pigs

Hetty Μ. G. van Beers-Schreurs From the Department of Large Animal Medicine and Nutrition, Utrecht University, Utrecht, The Netherlands (van Beers-Schreurs, Vellenga, Wensing, Breukink); and the Institute for Animal Science and Health, Lelystad, The Netherlands (Nabuurs).

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Μ. J. A. Nabuurs From the Department of Large Animal Medicine and Nutrition, Utrecht University, Utrecht, The Netherlands (van Beers-Schreurs, Vellenga, Wensing, Breukink); and the Institute for Animal Science and Health, Lelystad, The Netherlands (Nabuurs).

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L. Vellenga From the Department of Large Animal Medicine and Nutrition, Utrecht University, Utrecht, The Netherlands (van Beers-Schreurs, Vellenga, Wensing, Breukink); and the Institute for Animal Science and Health, Lelystad, The Netherlands (Nabuurs).

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Th. Wensing From the Department of Large Animal Medicine and Nutrition, Utrecht University, Utrecht, The Netherlands (van Beers-Schreurs, Vellenga, Wensing, Breukink); and the Institute for Animal Science and Health, Lelystad, The Netherlands (Nabuurs).

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H. J. Breukink From the Department of Large Animal Medicine and Nutrition, Utrecht University, Utrecht, The Netherlands (van Beers-Schreurs, Vellenga, Wensing, Breukink); and the Institute for Animal Science and Health, Lelystad, The Netherlands (Nabuurs).

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Abstract

Objective

To determine whether the large intestine may have a role in counterbalancing the loss of fluid from the small intestine of pigs with diarrhea.

Animals

2 groups of pigs (1 from a specific-pathogen-free herd and 1 from a herd with a history of diarrhea).

Procedure

At weaning and 4, 7, 11, and 14 days after weaning, the percentage of dry matter in the large intestinal contents, total and individual concentrations of volatile fatty acids in large-intestinal contents and blood, and concentration of aldosterone in the blood were measured.

Results

Large intestinal contents of pigs with diarrhea had a lower percentage of dry matter, lower acetate and butyrate concentrations, and higher propionate concentrations than did those of specific-pathogen-free pigs, and blood of pigs with diarrhea also had lower total volatile fatty acids concentration, higher aldosterone concentration, and lower sodium concentration.

Clinical Relevance

The large intestine has a role in the pathogenesis of diarrhea in weaned pigs. (Am J Vet Res 1998;59:696-703)

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Cover American Journal of Veterinary Research
American Journal of Veterinary Research
Issue:
01 Jun 1998
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