Evaluation of platelet activation and platelet-neutrophil aggregates in Thoroughbreds undergoing near-maximal treadmill exercise

Douglas J. Weiss From the Departments of Veterinary PathoBiology (Weiss, Evanson, Fagliari) and Clinical and Population Sciences (Valberg), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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Oral A. Evanson From the Departments of Veterinary PathoBiology (Weiss, Evanson, Fagliari) and Clinical and Population Sciences (Valberg), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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José J. Fagliari From the Departments of Veterinary PathoBiology (Weiss, Evanson, Fagliari) and Clinical and Population Sciences (Valberg), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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Stephanie Valberg From the Departments of Veterinary PathoBiology (Weiss, Evanson, Fagliari) and Clinical and Population Sciences (Valberg), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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Abstract

Objectives

To determine whether platelets become activated and form platelet-neutrophil aggregates during near-maximal treadmill exercise in horses.

Animals

4 Thoroughbreds.

Procedure

Horses were subjected to 4 standardized exercise tests on a treadmill, and blood samples were collected before exercise, at treadmill speed of 12 m/s, and 5 minutes after exercise. Flow cytometric techniques were used to identify activated platelets, and flow cytometric and microscopic techniques were used to identify platelet-neutrophil aggregates.

Results

Platelet-neutrophil aggregates increased from 2.8 ± 0.4% at rest to 17.2 ± 1.1% and 14.7 ± 1.6% during and after exercise, respectively. Platelet activation was not detected during or after exercise.

Conclusions

Platelet-neutrophil aggregates consistently form during strenuous exercise in horses. (Am J Vet Res 1998;59:393–396)

Abstract

Objectives

To determine whether platelets become activated and form platelet-neutrophil aggregates during near-maximal treadmill exercise in horses.

Animals

4 Thoroughbreds.

Procedure

Horses were subjected to 4 standardized exercise tests on a treadmill, and blood samples were collected before exercise, at treadmill speed of 12 m/s, and 5 minutes after exercise. Flow cytometric techniques were used to identify activated platelets, and flow cytometric and microscopic techniques were used to identify platelet-neutrophil aggregates.

Results

Platelet-neutrophil aggregates increased from 2.8 ± 0.4% at rest to 17.2 ± 1.1% and 14.7 ± 1.6% during and after exercise, respectively. Platelet activation was not detected during or after exercise.

Conclusions

Platelet-neutrophil aggregates consistently form during strenuous exercise in horses. (Am J Vet Res 1998;59:393–396)

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