Myoelectric activity of the ileum, cecum, and right ventral colon, and cecal emptying of radiolabeled markers in clinically normal ponies

Guy D. Lester From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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A. M. Merritt From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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Lisa Neuwirth From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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Tamara Vetro-Widenhouse From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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Christine Steible From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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Brett Rice From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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Danielle F. Mauragis From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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John B. Madison From the Departments of Large Animal Clinical Sciences (Lester, Merritt, Vetro-Widenhouse, Rice, Madison) and Small Animal Clinical Sciences (Neuwirth, Mauragis), College of Veterinary Medicine, and the Department of Statistics (Steible), University of Florida, Gainesville, FL 32610-0125,

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Abstract

Objectives

To determine normal cecal emptying curves for liquid- and solid-phase radiolabeled markers and to further define myoelectric patterns of the ileum, cecum, and colon in healthy ponies.

Animals

6 adult ponies.

Procedure

A cecal cannula and 12 bipolar Ag-AgCl recording electrodes were sutured to the ileum, cecum, and right ventral colon of the ponies. Radioisotopes, indium 111-labeled diethyltriaminepentaacetic acid (111In-DTPA) and technetium 99m (99mTc)-labeled sulfur colloid bound to egg albumen, were introduced through the cannula directly into the cecal body. Movement of these markers from the cecum was monitored by a gamma camera, and power exponential clearance curves were generated. Myoelectric data were collected before and after IV administration of isotonic saline (0.9% NaCl) solution, and were analyzed for spike burst (SB) rate, relative activity index, and mean burst duration. Myoelectric complexes were identified from observation of chart recordings or compressed, digitized data.

Results

Clearance curves were generated for liquid (111In-DTPA)- and solid (99mTc)-phase markers. Marker types were not different with respect to lag phase, but liquid markers emptied at a slightly faster rate than did solids. Baseline values were calculated after saline solution administration for each of the myoelectric variables investigated. A relation between ileal, cecal, and colonic myoelectric activity was identified. Activity consistent with the previously described colonic migrating myoelectric complex in the pelvic flexure was identified in the right ventral colon.

Conclusions and Clinical Relevance

Baseline data on normal cecal emptying was obtained; this technique could be used to evaluate the effect of postulated motility-modifying treatments used in equine practice. (Am J Vet Res 1998;59:313–319)

Abstract

Objectives

To determine normal cecal emptying curves for liquid- and solid-phase radiolabeled markers and to further define myoelectric patterns of the ileum, cecum, and colon in healthy ponies.

Animals

6 adult ponies.

Procedure

A cecal cannula and 12 bipolar Ag-AgCl recording electrodes were sutured to the ileum, cecum, and right ventral colon of the ponies. Radioisotopes, indium 111-labeled diethyltriaminepentaacetic acid (111In-DTPA) and technetium 99m (99mTc)-labeled sulfur colloid bound to egg albumen, were introduced through the cannula directly into the cecal body. Movement of these markers from the cecum was monitored by a gamma camera, and power exponential clearance curves were generated. Myoelectric data were collected before and after IV administration of isotonic saline (0.9% NaCl) solution, and were analyzed for spike burst (SB) rate, relative activity index, and mean burst duration. Myoelectric complexes were identified from observation of chart recordings or compressed, digitized data.

Results

Clearance curves were generated for liquid (111In-DTPA)- and solid (99mTc)-phase markers. Marker types were not different with respect to lag phase, but liquid markers emptied at a slightly faster rate than did solids. Baseline values were calculated after saline solution administration for each of the myoelectric variables investigated. A relation between ileal, cecal, and colonic myoelectric activity was identified. Activity consistent with the previously described colonic migrating myoelectric complex in the pelvic flexure was identified in the right ventral colon.

Conclusions and Clinical Relevance

Baseline data on normal cecal emptying was obtained; this technique could be used to evaluate the effect of postulated motility-modifying treatments used in equine practice. (Am J Vet Res 1998;59:313–319)

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