Prediction of inherited portosystemic shunts in Irish Wolfhounds on the basis of pedigree analysis

Geert J. Ubbink From the Department of Clinical Sciences of Companion Animals (Ubbink, Meyer, Rothuizen) and the Center of Biostatistics (van de Broek), Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.

Search for other papers by Geert J. Ubbink in
Current site
Google Scholar
PubMed
Close
 DVM
,
Jan van de Broek From the Department of Clinical Sciences of Companion Animals (Ubbink, Meyer, Rothuizen) and the Center of Biostatistics (van de Broek), Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.

Search for other papers by Jan van de Broek in
Current site
Google Scholar
PubMed
Close
 PhD
,
Hein P. Meyer From the Department of Clinical Sciences of Companion Animals (Ubbink, Meyer, Rothuizen) and the Center of Biostatistics (van de Broek), Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.

Search for other papers by Hein P. Meyer in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Jan Rothuizen From the Department of Clinical Sciences of Companion Animals (Ubbink, Meyer, Rothuizen) and the Center of Biostatistics (van de Broek), Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.

Search for other papers by Jan Rothuizen in
Current site
Google Scholar
PubMed
Close
 DVM, PhD

Click on author name to view affiliation information

Abstract

Objective

To test validity of prediction for inherited portosystemic shunts (PSS) in Irish Wolfhounds, using nonselective clinical findings and a computerized database containing 5-generation pedigrees.

Animals

613 dogs in the first and 396 dogs in the second cohort.

Procedure

Preprandial venous ammonia concentration was measured at 6 to 8 weeks in all pups born between Jan 1, 1988 and Jan 1, 1997. Portosystemic shunts were confirmed in hyperammonemic pups, using radioisotope shunt index measurement, and diagnosis of shunting was confirmed at abdominal surgery or necropsy. Findings in dogs of the first cohort (born before Jan 1, 1992) were used to predict shunting in their offspring of the second cohort. Common ancestors of first-cohort dogs with shunts were tested for positive associations with the disease. Risk for a shunt in all second-cohort dogs was predicted on the basis of relatedness with founders and was compared with outcome of clinical screening.

Results

Prevalence of shunts in first and second cohorts was 3.1 and 2.3%, respectively. Fifteen highly related associated founders could be identified. Second-cohort dogs were classified into 6 groups of increasing predicted risk. Mean number of dogs per class was 60; number of clinically diagnosed cases ranged from 0 in the class with the lowest risk to 4 in the highest risk class.

Conclusions

Genetic risk for reproducing a PSS in Irish Wolfhounds was accurate, using the described method.

Clinical Relevance

Risk estimation provides a tool for genetic counseling, does not require knowledge of the mode of inheritance, and may be valid for any inherited disease. (Am J Vet Res 1998;59:1553-1556)

Abstract

Objective

To test validity of prediction for inherited portosystemic shunts (PSS) in Irish Wolfhounds, using nonselective clinical findings and a computerized database containing 5-generation pedigrees.

Animals

613 dogs in the first and 396 dogs in the second cohort.

Procedure

Preprandial venous ammonia concentration was measured at 6 to 8 weeks in all pups born between Jan 1, 1988 and Jan 1, 1997. Portosystemic shunts were confirmed in hyperammonemic pups, using radioisotope shunt index measurement, and diagnosis of shunting was confirmed at abdominal surgery or necropsy. Findings in dogs of the first cohort (born before Jan 1, 1992) were used to predict shunting in their offspring of the second cohort. Common ancestors of first-cohort dogs with shunts were tested for positive associations with the disease. Risk for a shunt in all second-cohort dogs was predicted on the basis of relatedness with founders and was compared with outcome of clinical screening.

Results

Prevalence of shunts in first and second cohorts was 3.1 and 2.3%, respectively. Fifteen highly related associated founders could be identified. Second-cohort dogs were classified into 6 groups of increasing predicted risk. Mean number of dogs per class was 60; number of clinically diagnosed cases ranged from 0 in the class with the lowest risk to 4 in the highest risk class.

Conclusions

Genetic risk for reproducing a PSS in Irish Wolfhounds was accurate, using the described method.

Clinical Relevance

Risk estimation provides a tool for genetic counseling, does not require knowledge of the mode of inheritance, and may be valid for any inherited disease. (Am J Vet Res 1998;59:1553-1556)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 26 26 6
PDF Downloads 19 19 3
Advertisement