Efficacy of imidacloprid for removal and control of fleas (Ctenocephalides felis) on dogs

Robert G. Arther From the Bayer Corporation, Agriculture Division, Animal Health, Shawnee Mission, KS 66202 (Arther); Ag Research Consultants Inc, Greenbrier, AR 72058 (Cunningham, Everett); Bayer AG Monheim, Germany (Dorn); Epidemiology Consulting Associates Inc, Exton, PA 19341 (Herr); and Bayer Australia Ltd, Beenleigh, Queensland, Australia (Hopkins).

Search for other papers by Robert G. Arther in
Current site
Google Scholar
PubMed
Close
 PhD
,
Jerry Cunningham From the Bayer Corporation, Agriculture Division, Animal Health, Shawnee Mission, KS 66202 (Arther); Ag Research Consultants Inc, Greenbrier, AR 72058 (Cunningham, Everett); Bayer AG Monheim, Germany (Dorn); Epidemiology Consulting Associates Inc, Exton, PA 19341 (Herr); and Bayer Australia Ltd, Beenleigh, Queensland, Australia (Hopkins).

Search for other papers by Jerry Cunningham in
Current site
Google Scholar
PubMed
Close
 MS
,
Hubert Dorn From the Bayer Corporation, Agriculture Division, Animal Health, Shawnee Mission, KS 66202 (Arther); Ag Research Consultants Inc, Greenbrier, AR 72058 (Cunningham, Everett); Bayer AG Monheim, Germany (Dorn); Epidemiology Consulting Associates Inc, Exton, PA 19341 (Herr); and Bayer Australia Ltd, Beenleigh, Queensland, Australia (Hopkins).

Search for other papers by Hubert Dorn in
Current site
Google Scholar
PubMed
Close
 DVM
,
Ronald Everett From the Bayer Corporation, Agriculture Division, Animal Health, Shawnee Mission, KS 66202 (Arther); Ag Research Consultants Inc, Greenbrier, AR 72058 (Cunningham, Everett); Bayer AG Monheim, Germany (Dorn); Epidemiology Consulting Associates Inc, Exton, PA 19341 (Herr); and Bayer Australia Ltd, Beenleigh, Queensland, Australia (Hopkins).

Search for other papers by Ronald Everett in
Current site
Google Scholar
PubMed
Close
 PhD
,
Leslie G. Herr From the Bayer Corporation, Agriculture Division, Animal Health, Shawnee Mission, KS 66202 (Arther); Ag Research Consultants Inc, Greenbrier, AR 72058 (Cunningham, Everett); Bayer AG Monheim, Germany (Dorn); Epidemiology Consulting Associates Inc, Exton, PA 19341 (Herr); and Bayer Australia Ltd, Beenleigh, Queensland, Australia (Hopkins).

Search for other papers by Leslie G. Herr in
Current site
Google Scholar
PubMed
Close
 DVM
, and
Terence Hopkins From the Bayer Corporation, Agriculture Division, Animal Health, Shawnee Mission, KS 66202 (Arther); Ag Research Consultants Inc, Greenbrier, AR 72058 (Cunningham, Everett); Bayer AG Monheim, Germany (Dorn); Epidemiology Consulting Associates Inc, Exton, PA 19341 (Herr); and Bayer Australia Ltd, Beenleigh, Queensland, Australia (Hopkins).

Search for other papers by Terence Hopkins in
Current site
Google Scholar
PubMed
Close
 BVSc

Click on author name to view affiliation information

Abstract

Objective

To evaluate efficacy of a 9.1% (w/w) imidacloprid solution, applied topically, to remove fleas from dogs and the duration of residual flea control when dogs were exposed to continuing flea infestation.

Animals

32 adult mixed-breed dogs.

Procedure

Dogs were allocated to 4 groups of 8 dogs each; dogs of 3 groups received a single dose of imidacloprid, and those of the fourth group received excipient. Each dog was infested with 100 adult fleas on study days -3, -1, 6, 13, 20, 27, and 33. Treatments were applied on day 0. Each dog was examined for live fleas on days -2, 1, 7, 14, 21, 28, and 34. Posttreatment efficacy was determined by comparing the mean number of live fleas remaining on the treated dogs with the mean number of live fleas remaining on the control dogs.

Results

All 3 imidacloprid dosages provided flea control ≥ 96.9% one day after treatment. Maximal efficacy of all 3 dosages (99.1 to 100%) was observed at 7 days after treatment. Flea control with 3.75 mg of imidacloprid/kg of body weight ranged from 94.4 to 96.9% for days 14 to 28 and decreased to 91.6% by 34 days after treatment. Flea control with 7.5 and 10.0 mg of imidacloprid/kg was 97.8 to 100% through day 28. At day 34, dosages of 7.5 and 10.0 mg of imidacloprid/kg were 97.6 and 96.9% efficacious, respectively.

Conclusion

7.5 or 10.0 mg of imidacloprid/kg are equivalent and superior to 3.75 mg/kg for flea control over the course of a 34 day posttreatment period.

Clinical Relevance

Monthly imidacloprid application of 7.5 to 10 mg/kg will rapidly kill existing and reinfesting flea infestations on dogs and break the flea life cycle by killing adult fleas before egg production begins. (Am J Vet Res 1997;58:848–850)

Abstract

Objective

To evaluate efficacy of a 9.1% (w/w) imidacloprid solution, applied topically, to remove fleas from dogs and the duration of residual flea control when dogs were exposed to continuing flea infestation.

Animals

32 adult mixed-breed dogs.

Procedure

Dogs were allocated to 4 groups of 8 dogs each; dogs of 3 groups received a single dose of imidacloprid, and those of the fourth group received excipient. Each dog was infested with 100 adult fleas on study days -3, -1, 6, 13, 20, 27, and 33. Treatments were applied on day 0. Each dog was examined for live fleas on days -2, 1, 7, 14, 21, 28, and 34. Posttreatment efficacy was determined by comparing the mean number of live fleas remaining on the treated dogs with the mean number of live fleas remaining on the control dogs.

Results

All 3 imidacloprid dosages provided flea control ≥ 96.9% one day after treatment. Maximal efficacy of all 3 dosages (99.1 to 100%) was observed at 7 days after treatment. Flea control with 3.75 mg of imidacloprid/kg of body weight ranged from 94.4 to 96.9% for days 14 to 28 and decreased to 91.6% by 34 days after treatment. Flea control with 7.5 and 10.0 mg of imidacloprid/kg was 97.8 to 100% through day 28. At day 34, dosages of 7.5 and 10.0 mg of imidacloprid/kg were 97.6 and 96.9% efficacious, respectively.

Conclusion

7.5 or 10.0 mg of imidacloprid/kg are equivalent and superior to 3.75 mg/kg for flea control over the course of a 34 day posttreatment period.

Clinical Relevance

Monthly imidacloprid application of 7.5 to 10 mg/kg will rapidly kill existing and reinfesting flea infestations on dogs and break the flea life cycle by killing adult fleas before egg production begins. (Am J Vet Res 1997;58:848–850)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 71 71 14
PDF Downloads 61 61 10
Advertisement