Endocrine changes in cerebrospinal fluid, pituitary effluent, and peripheral plasma of anesthetized ponies
Search for other papers by Stelio P. L. Luna in
Current site
Google Scholar
PubMed
Search for other papers by Polly M. Taylor in
Current site
Google Scholar
PubMed
Search for other papers by Malcolm Bloomfield in
Current site
Google Scholar
PubMed
Abstract
Objective
To investigate the effects of inhalation and total IV anesthesia on pituitary-adrenal activity in ponies.
Animals
9 healthy ponies: 5 geldings and 4 mares.
Procedure
Catheters were placed in the cavernous sinus below the pituitary gland and in the subarachnoid space via the lumbosacral space. After 72 hours, administration of acepromazine was followed by induction of anesthesia with thiopentone and maintenance with halothane (halothane protocol), or for the IV protocol, anesthesia induction with detomidine and ketamine was followed by maintenance with IV infusion of a detomidine-ketamine-guaifenesin combination. Arterial blood pressure and gas tensions were measured throughout anesthesia. Peptide and catecholamine concentrations were measured in pituitary effluent, peripheral plasma, and CSF. Peripheral plasma cortisol, glucose, and lactate concentrations also were measured.
Results
Intravenous anesthesia caused less cardiorespiratory depression than did halothane. ACTH, metenkephalin, arginine vasopressin, and norepinephrine pituitary effluent and peripheral plasma concentrations were higher during halothane anesthesia, with little change during intravenous anesthesia. Pituitary effluent plasma β-endorphin and peripheral plasma cortisol concentrations increased during halothane anesthesia only. Dynorphin concentrations did not change in either group. Hyperglycemia developed during intravenous anesthesia only. Minimal changes occurred in CSF hormonal concentrations during anesthesia.
Conclusion
The pituitary gland has a major role in maintaining circulating peptides during anesthesia. Compared with halothane, IV anesthesia appeared to suppress pituitary secretion. (Am J Vet Res 1997;58:765–770)
| All Time | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 0 | 0 | 0 |
| Full Text Views | 5792 | 5587 | 102 |
| PDF Downloads | 52 | 29 | 2 |
