Comparison of intratumoral administration of cisplatin versus bleomycin for treatment of periocular squamous cell carcinomas in horses

A. P. Théon From the Departments of Surgical and Radiological Sciences (Théon, Pascoe, Metzger) and Medicine and Epidemiology (Madigan, Carlson), School of Veterinary Medicine, University of California, Davis, CA 95616-8745.

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J. R. Pascoe From the Departments of Surgical and Radiological Sciences (Théon, Pascoe, Metzger) and Medicine and Epidemiology (Madigan, Carlson), School of Veterinary Medicine, University of California, Davis, CA 95616-8745.

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J. E. Madigan From the Departments of Surgical and Radiological Sciences (Théon, Pascoe, Metzger) and Medicine and Epidemiology (Madigan, Carlson), School of Veterinary Medicine, University of California, Davis, CA 95616-8745.

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G. Carlson From the Departments of Surgical and Radiological Sciences (Théon, Pascoe, Metzger) and Medicine and Epidemiology (Madigan, Carlson), School of Veterinary Medicine, University of California, Davis, CA 95616-8745.

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L. Metzger From the Departments of Surgical and Radiological Sciences (Théon, Pascoe, Metzger) and Medicine and Epidemiology (Madigan, Carlson), School of Veterinary Medicine, University of California, Davis, CA 95616-8745.

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Abstract

Objective

To compare therapeutic benefits of intratumoral administration of cisplatin and bleomycin for squamous cell carcinoma of the eyelids in horses.

Animals

25 horses with 27 T2-stage periocular squamous cell carcinomas.

Procedure

Horses were treated 4 times at 2-week intervals with a slow-release formulation of cisplatin (1 mg/cm3 of tissue) or bleomycin (1 IU/cm3 of tissue). A two-stage design was used to minimize the sample size in each treatment arm.

Results

The local control rate at 1 year for lesions treated with cisplatin was 93 ± 6%, and with bleomycin was 78 ± 10%. Difference in local control duration between the 2 treatment groups was not significantly different. A high tumor proliferative fraction index value was associated with a higher local (in-field) control rate, but also with a higher risk of marginal and regional recurrences. Tumors with a low proliferative fraction index value (< 28%) had 9.5-times higher (P = 0.0411) risk of recurrence than those with a high index value. Local acute reactions were similar in the 2 treatment groups, and chronic reactions were not observed.

Conclusions

Cisplatin and bleomycin were effective anticancer agents for carcinoma of the eyelid in horses. Based on therapeutic benefit and treatment cost, cisplatin was found to be a better choice for intratumoral chemotherapy of eyelid carcinomas.

Clinical Relevance

Results of this study confirm the value of intratumoral chemotherapy, using cisplatin, for treatment of cutaneous squamous cell carcinomas in horses. (Am J Vet Res 1997;58:431–436)

Abstract

Objective

To compare therapeutic benefits of intratumoral administration of cisplatin and bleomycin for squamous cell carcinoma of the eyelids in horses.

Animals

25 horses with 27 T2-stage periocular squamous cell carcinomas.

Procedure

Horses were treated 4 times at 2-week intervals with a slow-release formulation of cisplatin (1 mg/cm3 of tissue) or bleomycin (1 IU/cm3 of tissue). A two-stage design was used to minimize the sample size in each treatment arm.

Results

The local control rate at 1 year for lesions treated with cisplatin was 93 ± 6%, and with bleomycin was 78 ± 10%. Difference in local control duration between the 2 treatment groups was not significantly different. A high tumor proliferative fraction index value was associated with a higher local (in-field) control rate, but also with a higher risk of marginal and regional recurrences. Tumors with a low proliferative fraction index value (< 28%) had 9.5-times higher (P = 0.0411) risk of recurrence than those with a high index value. Local acute reactions were similar in the 2 treatment groups, and chronic reactions were not observed.

Conclusions

Cisplatin and bleomycin were effective anticancer agents for carcinoma of the eyelid in horses. Based on therapeutic benefit and treatment cost, cisplatin was found to be a better choice for intratumoral chemotherapy of eyelid carcinomas.

Clinical Relevance

Results of this study confirm the value of intratumoral chemotherapy, using cisplatin, for treatment of cutaneous squamous cell carcinomas in horses. (Am J Vet Res 1997;58:431–436)

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