Effects of continuous venovenous hemofiltration on cardiopulmonary function in a porcine model of endotoxin-induced shock

E. D. Murphey From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by E. D. Murphey in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
J. F. Fessler From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by J. F. Fessler in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
G. D. Bottoms From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by G. D. Bottoms in
Current site
Google Scholar
PubMed
Close
 PhD
,
H. Latshaw From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by H. Latshaw in
Current site
Google Scholar
PubMed
Close
 MS
,
M. Johnson From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by M. Johnson in
Current site
Google Scholar
PubMed
Close
 MS
,
B. Mueller From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by B. Mueller in
Current site
Google Scholar
PubMed
Close
 PharmD, MS
,
W. Clark From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by W. Clark in
Current site
Google Scholar
PubMed
Close
 MD
, and
W. Macias From the Departments of Veterinary Clinical Sciences (Murphey, Fessier, Latshaw) and Basic Medical Sciences (Bottoms, Johnson), School of Veterinary Medicine, and the Department of Pharmacy Practice (Mueller), School of Pharmacy, Purdue University, West Lafayette, IN 47907, and the Department of Medicine (Clark, Macias), School of Medicine, Indiana University, Indianapolis, IN 46202.

Search for other papers by W. Macias in
Current site
Google Scholar
PubMed
Close
 MD, PhD

Click on author name to view affiliation information

Abstract

Objective

To determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock.

Animals

16 clinically normal pigs.

Procedure

Endotoxin was infused, IV, into anesthetized pigs for a total of 50 minutes. Thirty minutes after termination of the infusion period, extracorporeal circulation was initiated through a 50-kd diafilter, or past the filter without ultrafiltrate formation. Cardiac and respiratory variables were monitored for a period of 4 hours.

Results

Infusion of lipopolysaccharide resulted in a severe hypodynamic circulatory state, with significant decreases in mean arterial pressure and cardiac output concurrent with a significant increase in pulmonary arterial pressure. Hemofiltration was not associated with any correction of lipopolysaccharide-induced cardiopulmonary derangements.

Conclusions

Continuous venovenous hemofiltration, as used in this acute experiment, did not improve cardiopulmonary dysfunction during endotoxic shock.

Clinical Relevance

Continuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment. (Am J Vet Res 1997;58:408–413)

Abstract

Objective

To determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock.

Animals

16 clinically normal pigs.

Procedure

Endotoxin was infused, IV, into anesthetized pigs for a total of 50 minutes. Thirty minutes after termination of the infusion period, extracorporeal circulation was initiated through a 50-kd diafilter, or past the filter without ultrafiltrate formation. Cardiac and respiratory variables were monitored for a period of 4 hours.

Results

Infusion of lipopolysaccharide resulted in a severe hypodynamic circulatory state, with significant decreases in mean arterial pressure and cardiac output concurrent with a significant increase in pulmonary arterial pressure. Hemofiltration was not associated with any correction of lipopolysaccharide-induced cardiopulmonary derangements.

Conclusions

Continuous venovenous hemofiltration, as used in this acute experiment, did not improve cardiopulmonary dysfunction during endotoxic shock.

Clinical Relevance

Continuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment. (Am J Vet Res 1997;58:408–413)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 36 36 4
PDF Downloads 20 20 4
Advertisement