Efficacy of fenbendazole for treatment of giardiasis in calves

R. M. O'Handley From the Gastrointestinal Research Group (O'Handley, Olson) and Animal Health Unit (Olson, Morck), University of Calgary, Calgary, Alberta, Canada T2N 4N1; Agriculture and Agrifood Canada Lethbridge Research Centre, Lethbridge, Alberta, Canada T1J 4B1 (Cheng, McAllister); and Hoechst Animal Health, Regina, Saskatchewan, Canada S7N 5B4 (Jelinski, Royan).

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M. E. Olson From the Gastrointestinal Research Group (O'Handley, Olson) and Animal Health Unit (Olson, Morck), University of Calgary, Calgary, Alberta, Canada T2N 4N1; Agriculture and Agrifood Canada Lethbridge Research Centre, Lethbridge, Alberta, Canada T1J 4B1 (Cheng, McAllister); and Hoechst Animal Health, Regina, Saskatchewan, Canada S7N 5B4 (Jelinski, Royan).

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T. A. McAllister From the Gastrointestinal Research Group (O'Handley, Olson) and Animal Health Unit (Olson, Morck), University of Calgary, Calgary, Alberta, Canada T2N 4N1; Agriculture and Agrifood Canada Lethbridge Research Centre, Lethbridge, Alberta, Canada T1J 4B1 (Cheng, McAllister); and Hoechst Animal Health, Regina, Saskatchewan, Canada S7N 5B4 (Jelinski, Royan).

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D.W. Morck From the Gastrointestinal Research Group (O'Handley, Olson) and Animal Health Unit (Olson, Morck), University of Calgary, Calgary, Alberta, Canada T2N 4N1; Agriculture and Agrifood Canada Lethbridge Research Centre, Lethbridge, Alberta, Canada T1J 4B1 (Cheng, McAllister); and Hoechst Animal Health, Regina, Saskatchewan, Canada S7N 5B4 (Jelinski, Royan).

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M. Jelinski From the Gastrointestinal Research Group (O'Handley, Olson) and Animal Health Unit (Olson, Morck), University of Calgary, Calgary, Alberta, Canada T2N 4N1; Agriculture and Agrifood Canada Lethbridge Research Centre, Lethbridge, Alberta, Canada T1J 4B1 (Cheng, McAllister); and Hoechst Animal Health, Regina, Saskatchewan, Canada S7N 5B4 (Jelinski, Royan).

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G. Royan From the Gastrointestinal Research Group (O'Handley, Olson) and Animal Health Unit (Olson, Morck), University of Calgary, Calgary, Alberta, Canada T2N 4N1; Agriculture and Agrifood Canada Lethbridge Research Centre, Lethbridge, Alberta, Canada T1J 4B1 (Cheng, McAllister); and Hoechst Animal Health, Regina, Saskatchewan, Canada S7N 5B4 (Jelinski, Royan).

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K.-J. Cheng From the Gastrointestinal Research Group (O'Handley, Olson) and Animal Health Unit (Olson, Morck), University of Calgary, Calgary, Alberta, Canada T2N 4N1; Agriculture and Agrifood Canada Lethbridge Research Centre, Lethbridge, Alberta, Canada T1J 4B1 (Cheng, McAllister); and Hoechst Animal Health, Regina, Saskatchewan, Canada S7N 5B4 (Jelinski, Royan).

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Abstract

Objective

To determine efficacy of fenbendazole for treatment of giardiasis in calves.

Animals

Twenty male and 15 female Holstein calves (100 to 180 kg), naturally infected with Giardia sp.

Procedure

In vitro fenbendazole susceptibility and resistance development was determined for a ruminant Giardia isolate by use of an adherence assay. Calves were treated as follows: group 1, a single administration of 5 mg of fenbendazole/kg of body weight; group 2, a single administration of 10 mg of fenbendazole/kg; group 3, 5 mg of fenbendazole/kg, every 24 hours for 3 days; group 4, 10 mg of fenbendazole/kg, every 24 hours for 3 days; group 5, 20 mg of fenbendazole/kg, every 24 hours for 3 days; group 6, 0.833 mg of fenbendazole/kg, every 24 hours for 6 days; and group 7, saline solution, Fecal Giardia cysts were counted on days −3 through −1 and 1 through 7, 9, 11, 13, 21, and 28 by use of sucrose gradient concentration and staining with a fluorescent monoclonal antibody.

Results

The 50% adherence inhibition concentration was 0.024 ± 0.002 μg/ml, and resistance could not be detected after 5 weeks of continuous culture at sublethal concentration of fenbendazole (0.01 μg/kg). Fenbendazole was 100% effective in eliminating cysts from the feces within 6 days for calves in treatment groups 2–6. Reinfection was observed in some calves within the 28-day study period.

Conclusions

Fenbendazole is effective in the elimination of Giardia infections in calves, but repeat treatments may be required in reinfected animals.

Clinical Relevance

Fenbendazole is an effective and economical treatment for Giardia-associated diarrhea and growth rate reduction in calves. (Am J Vet Res 1997;58:384–388)

Abstract

Objective

To determine efficacy of fenbendazole for treatment of giardiasis in calves.

Animals

Twenty male and 15 female Holstein calves (100 to 180 kg), naturally infected with Giardia sp.

Procedure

In vitro fenbendazole susceptibility and resistance development was determined for a ruminant Giardia isolate by use of an adherence assay. Calves were treated as follows: group 1, a single administration of 5 mg of fenbendazole/kg of body weight; group 2, a single administration of 10 mg of fenbendazole/kg; group 3, 5 mg of fenbendazole/kg, every 24 hours for 3 days; group 4, 10 mg of fenbendazole/kg, every 24 hours for 3 days; group 5, 20 mg of fenbendazole/kg, every 24 hours for 3 days; group 6, 0.833 mg of fenbendazole/kg, every 24 hours for 6 days; and group 7, saline solution, Fecal Giardia cysts were counted on days −3 through −1 and 1 through 7, 9, 11, 13, 21, and 28 by use of sucrose gradient concentration and staining with a fluorescent monoclonal antibody.

Results

The 50% adherence inhibition concentration was 0.024 ± 0.002 μg/ml, and resistance could not be detected after 5 weeks of continuous culture at sublethal concentration of fenbendazole (0.01 μg/kg). Fenbendazole was 100% effective in eliminating cysts from the feces within 6 days for calves in treatment groups 2–6. Reinfection was observed in some calves within the 28-day study period.

Conclusions

Fenbendazole is effective in the elimination of Giardia infections in calves, but repeat treatments may be required in reinfected animals.

Clinical Relevance

Fenbendazole is an effective and economical treatment for Giardia-associated diarrhea and growth rate reduction in calves. (Am J Vet Res 1997;58:384–388)

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