Efficacy of a pour-on formulation of eprinomectin (MK-397) against nematode parasites of cattle, with emphasis on inhibited early fourth-stage larvae of Ostertagia spp

J. C. Williams From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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J. A. Stuedemann From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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K. Bairden From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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D. Kerboeuf From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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H. Ciordia From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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J. Hubert From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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S. D. Broussard From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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R. E. Plue From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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R. Alva-Valdes From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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D. G. Baggott From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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N. Pinkall From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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J. S. Eagleson From the Department of Veterinary Science, Louisiana Agricultural Experiment Station, LSU Agricultural Center, Baton Rouge, LA 70803-6002 (Williams, Broussard); USDA, ARS, Southern Piedmont Conservation Research Center, PO Box 555, Watkinsville, GA 30677 and Cattle Parasite Research Laboratory, Georgia Agricultural Experiment Station, Experiment, GA 30212 (Stuedemann, Ciordia); the University of Glasgow, Veterinary School, Bearsden Rd, Glasgow, Scotland G61 1QH UK (Bairden); INRA, Station de Pathologic Aviaire et de Parasitologie, Unité d'Helminthologic, 37380 Nouzilly, France (Kerboeuf, Hubert); and Merck & Co Inc, PO Box 2000, Rahway, NJ 07065 (Plue, Alva-Valdes, Baggott, Pinkall, Eagleson).

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Abstract

Objective

To evaluate efficacy of topically applied eprinomectin against inhibited early fourth-stage larvae (IL4) of Ostertagia spp in calves.

Animals

4 groups (n = 6 [replicates]) for dose titration; 2 groups (n = 8 calves [replicates]) for dose confirmation.

Procedure

2 dose titration studies—0, 125, 250, and 500 μg of eprinomectin/kg of body weight—Louisiana and Georgia—and 2 dose confirmation studies of selected therapeutic dosage (500 μg/kg) in Scotland and France. Monitor calves were used to determine inhibition percentage of Ostertagia IL4. Test calves were ranked by weight in replicates of 4 (titration trials) or 2 (confirmation trials) animals each, and within replicates, were randomly allocated to treatment groups. Drug treatments were done on day 0, and animals were euthanatized by replicate, with holding time between treatment and euthanasia varying among trials from 14 to 27 days.

Results

Observations indicated high efficacy (> 99%) of 500 μg of eprinomectin/kg in removal of Ostertagia IL4. Ostertagia and Cooperia were only genera common across sites, with efficacy of aforementioned dosage against adult and larval stages of both genera consistently high (> 99%). Results of 1 or both titration studies (500 μg/kg) indicated > 99 to 100% efficacy against adult Haemonchus placei, Trichostrongylus axei, T colubriformis, Bunostomum phlebotomum, Dictyocaulus viviparus, and Oesophagostomum radiatum. Lower efficacy values were observed at minimal (125 μg/kg) dosage. In France, 500 μg/kg was 85% effective against Trichostrongylus spp adults; however, numbers of control calves infected with Trichostrongylus spp and degree of infection were low, Adverse reactions were not evident.

Conclusion

Eprinomectin given topically (500 μg) was highly effective against Ostertagia IL4 and other common nematodes of cattle. (Am J Vet Res 1997; 58:379–383)

Abstract

Objective

To evaluate efficacy of topically applied eprinomectin against inhibited early fourth-stage larvae (IL4) of Ostertagia spp in calves.

Animals

4 groups (n = 6 [replicates]) for dose titration; 2 groups (n = 8 calves [replicates]) for dose confirmation.

Procedure

2 dose titration studies—0, 125, 250, and 500 μg of eprinomectin/kg of body weight—Louisiana and Georgia—and 2 dose confirmation studies of selected therapeutic dosage (500 μg/kg) in Scotland and France. Monitor calves were used to determine inhibition percentage of Ostertagia IL4. Test calves were ranked by weight in replicates of 4 (titration trials) or 2 (confirmation trials) animals each, and within replicates, were randomly allocated to treatment groups. Drug treatments were done on day 0, and animals were euthanatized by replicate, with holding time between treatment and euthanasia varying among trials from 14 to 27 days.

Results

Observations indicated high efficacy (> 99%) of 500 μg of eprinomectin/kg in removal of Ostertagia IL4. Ostertagia and Cooperia were only genera common across sites, with efficacy of aforementioned dosage against adult and larval stages of both genera consistently high (> 99%). Results of 1 or both titration studies (500 μg/kg) indicated > 99 to 100% efficacy against adult Haemonchus placei, Trichostrongylus axei, T colubriformis, Bunostomum phlebotomum, Dictyocaulus viviparus, and Oesophagostomum radiatum. Lower efficacy values were observed at minimal (125 μg/kg) dosage. In France, 500 μg/kg was 85% effective against Trichostrongylus spp adults; however, numbers of control calves infected with Trichostrongylus spp and degree of infection were low, Adverse reactions were not evident.

Conclusion

Eprinomectin given topically (500 μg) was highly effective against Ostertagia IL4 and other common nematodes of cattle. (Am J Vet Res 1997; 58:379–383)

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