Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum

Shin Oikawa From the Morioka Livestock Hygiene Service Center, Takizawa, Iwate 020-01 (Oikawa); the Laboratory of Biochemistry, National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba, Ibaraki 305 (Katoh); the Morioka Animal Health Center, Takizawa, Iwate 020-01 (Kawawa); and the Shiwa Meat Inspection Center, Shiwa, Iwate 028-33 (Ono), Japan.

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Norio Katoh From the Morioka Livestock Hygiene Service Center, Takizawa, Iwate 020-01 (Oikawa); the Laboratory of Biochemistry, National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba, Ibaraki 305 (Katoh); the Morioka Animal Health Center, Takizawa, Iwate 020-01 (Kawawa); and the Shiwa Meat Inspection Center, Shiwa, Iwate 028-33 (Ono), Japan.

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Fumio Kawawa From the Morioka Livestock Hygiene Service Center, Takizawa, Iwate 020-01 (Oikawa); the Laboratory of Biochemistry, National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba, Ibaraki 305 (Katoh); the Morioka Animal Health Center, Takizawa, Iwate 020-01 (Kawawa); and the Shiwa Meat Inspection Center, Shiwa, Iwate 028-33 (Ono), Japan.

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Yasushi Ono From the Morioka Livestock Hygiene Service Center, Takizawa, Iwate 020-01 (Oikawa); the Laboratory of Biochemistry, National Institute of Animal Health, 3-1-1 Kannondai, Tsukuba, Ibaraki 305 (Katoh); the Morioka Animal Health Center, Takizawa, Iwate 020-01 (Kawawa); and the Shiwa Meat Inspection Center, Shiwa, Iwate 028-33 (Ono), Japan.

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Abstract

Objective

To assess the relevance of hepatic lipidosis (fatty liver) in the development of ketosis and left displacement of the abomasum (LDA).

Sample Population

Sera from 22 healthy cows in early lactation. 21 cows with ketosis, and 19 cows with LDA, and serum and liver specimens from 35 slaughtered cows with or without fatty liver, ketosis, and/or LDA.

Procedure

Apolipoprotein B-100 and A-I concentrations were measured in sera of healthy farm cows and of farm cows with ketosis and LDA. Serum apolipoprotein concentration, together with liver triglyceride content, also were surveyed in a subset of slaughtered cows.

Results

Compared with those in healthy cows or controls, apolipoprotein B-100 and A-I concentrations were decreased in cows with ketosis and LDA.

Conclusions

Decreases in apolipoprotein B-100 and A-I concentrations in cows with ketosis and LDA indicate that the 2 disorders may be intimately associated with fatty liver.

Clinical Relevance

Monitoring of the apolipoprotein B-100 and A-I concentrations during the stages of nonlactation and early lactation is helpful for detecting cows susceptible to ketosis and LDA. (Am J Vet Res 1997;58:121–125)

Abstract

Objective

To assess the relevance of hepatic lipidosis (fatty liver) in the development of ketosis and left displacement of the abomasum (LDA).

Sample Population

Sera from 22 healthy cows in early lactation. 21 cows with ketosis, and 19 cows with LDA, and serum and liver specimens from 35 slaughtered cows with or without fatty liver, ketosis, and/or LDA.

Procedure

Apolipoprotein B-100 and A-I concentrations were measured in sera of healthy farm cows and of farm cows with ketosis and LDA. Serum apolipoprotein concentration, together with liver triglyceride content, also were surveyed in a subset of slaughtered cows.

Results

Compared with those in healthy cows or controls, apolipoprotein B-100 and A-I concentrations were decreased in cows with ketosis and LDA.

Conclusions

Decreases in apolipoprotein B-100 and A-I concentrations in cows with ketosis and LDA indicate that the 2 disorders may be intimately associated with fatty liver.

Clinical Relevance

Monitoring of the apolipoprotein B-100 and A-I concentrations during the stages of nonlactation and early lactation is helpful for detecting cows susceptible to ketosis and LDA. (Am J Vet Res 1997;58:121–125)

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