Quantification of antigen-specific antibody concentrations in tracheal lavage fluid of horses with summer pasture-associated obstructive pulmonary disease

Thomas L. Seahorn From the Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803 (Seahorn, Beadle), and the Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Veterinary Field Station, University of Edinburgh, Easter Bush, Roslin EH25 9RG, United Kingdom (McGorum, Marley).

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 DVM, MS
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Ralph E. Beadle From the Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803 (Seahorn, Beadle), and the Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Veterinary Field Station, University of Edinburgh, Easter Bush, Roslin EH25 9RG, United Kingdom (McGorum, Marley).

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 DVM, PhD
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Bruce C. McGorum From the Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803 (Seahorn, Beadle), and the Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Veterinary Field Station, University of Edinburgh, Easter Bush, Roslin EH25 9RG, United Kingdom (McGorum, Marley).

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 PhD, BSc, BVMS
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Christina L. Marley From the Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803 (Seahorn, Beadle), and the Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, Veterinary Field Station, University of Edinburgh, Easter Bush, Roslin EH25 9RG, United Kingdom (McGorum, Marley).

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 BSc

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SUMMARY

Objective

To determine whether horses with summer pasture-associated obstructive pulmonary disease (SPAOPD) have increased concentrations of antigen-specific IgG and IgE in tracheal lavage fluid, compared with values in clinically normal horses.

Animals

8 horses (6 females, 2 geldings; 6 Quarter Horses, 2 Appaloosas), 14 to 23 years old and with previous diagnosis of SPAOPD, served as the principal group; 8 horses (2 females, 6 geldings; 1 Quarter Horse, 7 Thoroughbreds), 6 to 9 years old, with no evidence of respiratory tract disease, served as the control group.

Procedure

Data were collected twice during a 1- year period: when all SPAOPD-affected horses were manifesting clinical signs of disease (July), and when all SPAOPD-affected horses appeared clinically normal (February). On each occasion, clinical evaluations were performed and blood and tracheal lavage fluid samples were collected. Transtracheal lavage supernatant was evaluated for mold antigen-specific IgG and IgE concentrations.

Results

Median IgE relative antibody unit (RAU) values were significantly higher in control, compared with principal, horses. The SPAOPD-affected horses had increased concentrations of specific IgG for only 1 antigen, during winter sample collection.

Conclusion

Antigen-specific IgG and IgE RAU values were not increased in SPAOPD-affected horses when these horses were manifesting clinical signs of disease. (Am J Vet Res 1997;58:1408–1411)

SUMMARY

Objective

To determine whether horses with summer pasture-associated obstructive pulmonary disease (SPAOPD) have increased concentrations of antigen-specific IgG and IgE in tracheal lavage fluid, compared with values in clinically normal horses.

Animals

8 horses (6 females, 2 geldings; 6 Quarter Horses, 2 Appaloosas), 14 to 23 years old and with previous diagnosis of SPAOPD, served as the principal group; 8 horses (2 females, 6 geldings; 1 Quarter Horse, 7 Thoroughbreds), 6 to 9 years old, with no evidence of respiratory tract disease, served as the control group.

Procedure

Data were collected twice during a 1- year period: when all SPAOPD-affected horses were manifesting clinical signs of disease (July), and when all SPAOPD-affected horses appeared clinically normal (February). On each occasion, clinical evaluations were performed and blood and tracheal lavage fluid samples were collected. Transtracheal lavage supernatant was evaluated for mold antigen-specific IgG and IgE concentrations.

Results

Median IgE relative antibody unit (RAU) values were significantly higher in control, compared with principal, horses. The SPAOPD-affected horses had increased concentrations of specific IgG for only 1 antigen, during winter sample collection.

Conclusion

Antigen-specific IgG and IgE RAU values were not increased in SPAOPD-affected horses when these horses were manifesting clinical signs of disease. (Am J Vet Res 1997;58:1408–1411)

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