Clinical evaluation of cimetidine, sucralfate, and misoprostol for prevention of gastrointestinal tract bleeding in dogs undergoing spinal surgery

Stephen Michael Hanson From the College of Veterinary Medicine and Biomedical Sciences, Colorado State University, F tCollins, CO 80523.

Search for other papers by Stephen Michael Hanson in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
David Robert Bostwick From the College of Veterinary Medicine and Biomedical Sciences, Colorado State University, F tCollins, CO 80523.

Search for other papers by David Robert Bostwick in
Current site
Google Scholar
PubMed
Close
 DVM, MS
,
David Cameron Twedt From the College of Veterinary Medicine and Biomedical Sciences, Colorado State University, F tCollins, CO 80523.

Search for other papers by David Cameron Twedt in
Current site
Google Scholar
PubMed
Close
 DVM, MS
, and
Mary Olivia Smith From the College of Veterinary Medicine and Biomedical Sciences, Colorado State University, F tCollins, CO 80523.

Search for other papers by Mary Olivia Smith in
Current site
Google Scholar
PubMed
Close
 BVM&S, PhD

Click on author name to view affiliation information

SUMMARY

Objective

To determine the incidence of gastrointestinal (GI) tract bleeding in dogs undergoing spinal surgery with adjunct corticosteroid treatment, and to determine the protective efficacy of cimetidine, sucralfate, and misoprostol against such bleeding in these dogs.

Animals

40 dogs that underwent spinal surgery.

Procedures

Myelography and surgery were performed on the first or second day of hospitalization. Methylprednisolone sodium succinate was given at a dosage of 30 mg/kg of body weight prior to myelography, followed by a second full or half dose 2 to 4 hours later at clinician discretion. Spinal surgery was performed in conventional manner, postoperative administration of analgesics was done, and dogs were fed a diet lacking red meat. Dogs were assigned at random to 1 of the 3 treatment groups or to the control group. Dogs of the treatment groups received cimetidine, sucralfate, or misoprostol. Physical examination and determination of PCV and serum total protein values were performed daily. A fecal sample was examined daily for gross and occult blood.

Results

36 of 40 dogs had GI tract bleeding during a hospitalization period of 3 to 6 days. There was no significant difference in development of bleeding between the control group and any of the treatment groups.

Conclusions

Gastrointestinal tract bleeding occurred in 90% of dogs undergoing spinal surgery combined with administration of methylprednisilone sodium succinate, a higher rate than that found in previous studies. This bleeding was not life-threatening. Prophylactic benefit from any of the GI protectants tested was not found. (Am J Vet Res 1997;58:1320–1323)

SUMMARY

Objective

To determine the incidence of gastrointestinal (GI) tract bleeding in dogs undergoing spinal surgery with adjunct corticosteroid treatment, and to determine the protective efficacy of cimetidine, sucralfate, and misoprostol against such bleeding in these dogs.

Animals

40 dogs that underwent spinal surgery.

Procedures

Myelography and surgery were performed on the first or second day of hospitalization. Methylprednisolone sodium succinate was given at a dosage of 30 mg/kg of body weight prior to myelography, followed by a second full or half dose 2 to 4 hours later at clinician discretion. Spinal surgery was performed in conventional manner, postoperative administration of analgesics was done, and dogs were fed a diet lacking red meat. Dogs were assigned at random to 1 of the 3 treatment groups or to the control group. Dogs of the treatment groups received cimetidine, sucralfate, or misoprostol. Physical examination and determination of PCV and serum total protein values were performed daily. A fecal sample was examined daily for gross and occult blood.

Results

36 of 40 dogs had GI tract bleeding during a hospitalization period of 3 to 6 days. There was no significant difference in development of bleeding between the control group and any of the treatment groups.

Conclusions

Gastrointestinal tract bleeding occurred in 90% of dogs undergoing spinal surgery combined with administration of methylprednisilone sodium succinate, a higher rate than that found in previous studies. This bleeding was not life-threatening. Prophylactic benefit from any of the GI protectants tested was not found. (Am J Vet Res 1997;58:1320–1323)

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 100 100 13
PDF Downloads 31 31 3
Advertisement