Effect of progesterone on prostaglandin F secretion and outcome of pregnancy during cloprostenol-induced abortion in mares

Peter F. Daels From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14855 (Daels, Besognel, Hansen, Mohammed), and Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University ol Agricultural Sciences. S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Bruno Besognet From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14855 (Daels, Besognel, Hansen, Mohammed), and Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University ol Agricultural Sciences. S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Betty Hansen From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14855 (Daels, Besognel, Hansen, Mohammed), and Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University ol Agricultural Sciences. S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Hussni Mohammed From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14855 (Daels, Besognel, Hansen, Mohammed), and Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University ol Agricultural Sciences. S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Kristina Odensvik From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14855 (Daels, Besognel, Hansen, Mohammed), and Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University ol Agricultural Sciences. S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Hans Kindahl From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14855 (Daels, Besognel, Hansen, Mohammed), and Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Swedish University ol Agricultural Sciences. S-75007 Uppsala, Sweden (Odensvik, Kindahl).

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Abstract

Objectives

To determine the role of progesterone in the regulation of endogenous prostaglandin F (PGF) secretion during cloprostenol-induced abortion and to investigate use of progestins to prevent prostaglandin-associated abortion.

Animals

16 pregnant mares.

Procedure

To induce abortion, cloprostenol (250 μg/d) was administered daily until fetal expulsion or for up to 5 days. In experiment 1, 8 mares, 98 to 153 days’ pregnant, received progesterone (300 mg/d) at 24-hour intervals for 5 days, starting 18 hours after the first cloprostenol administration. In experiment 2, 8 mares, 93 to 115 days’ pregnant, received altrenogest (44 mg/d) at 24-hour intervals, starting 12 hours after the first cloprostenol administration. Historic control mares, 82 to 102 days’ pregnant, received cloprostenol (250 μg/d) daily until fetal expulsion.

Results

In control mares, fetal expulsion occurred after 2 to 3 cloprostenol administrations and was associated with significant increases in PGF secretion. Abortion did not occur in 5 of 8 progesterone-treated mares and 8 of 8 altrenogest-treated mares, and endogenous PGF secretion was inhibited, compared with values in aborting mares.

Conclusion

Circulating progestogen concentrations may have a role in the outcome of pregnancy during prostaglandin-induced abortion. Altered prostaglandin secretion may be a reflection of a direct effect of progesterone or may be caused by the abortion process.

Clinical Relevance

Progestogens might be useful for prevention of abortion in mares in which pregnancy is at risk owing to diseases that are associated with excess prostaglandin secretion. (Am J Vet Res 1996;57:1331-1337)

Abstract

Objectives

To determine the role of progesterone in the regulation of endogenous prostaglandin F (PGF) secretion during cloprostenol-induced abortion and to investigate use of progestins to prevent prostaglandin-associated abortion.

Animals

16 pregnant mares.

Procedure

To induce abortion, cloprostenol (250 μg/d) was administered daily until fetal expulsion or for up to 5 days. In experiment 1, 8 mares, 98 to 153 days’ pregnant, received progesterone (300 mg/d) at 24-hour intervals for 5 days, starting 18 hours after the first cloprostenol administration. In experiment 2, 8 mares, 93 to 115 days’ pregnant, received altrenogest (44 mg/d) at 24-hour intervals, starting 12 hours after the first cloprostenol administration. Historic control mares, 82 to 102 days’ pregnant, received cloprostenol (250 μg/d) daily until fetal expulsion.

Results

In control mares, fetal expulsion occurred after 2 to 3 cloprostenol administrations and was associated with significant increases in PGF secretion. Abortion did not occur in 5 of 8 progesterone-treated mares and 8 of 8 altrenogest-treated mares, and endogenous PGF secretion was inhibited, compared with values in aborting mares.

Conclusion

Circulating progestogen concentrations may have a role in the outcome of pregnancy during prostaglandin-induced abortion. Altered prostaglandin secretion may be a reflection of a direct effect of progesterone or may be caused by the abortion process.

Clinical Relevance

Progestogens might be useful for prevention of abortion in mares in which pregnancy is at risk owing to diseases that are associated with excess prostaglandin secretion. (Am J Vet Res 1996;57:1331-1337)

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