Effects of vitamin E on mammary and blood leukocyte function, with emphasis on Chemotaxis, in periparturient dairy cows

I. Politis From the Department of Animal and Food Sciences, University of Vermont, Burlington, VT 05405 (Politis. Hidiroglou, White, Gilmore); Roche Vitamins and Fine Chemicals, Nutley, NJ 07110 (Williams, Schcrf); and Basel, Switzerland (Frigg).

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N. Hidiroglou From the Department of Animal and Food Sciences, University of Vermont, Burlington, VT 05405 (Politis. Hidiroglou, White, Gilmore); Roche Vitamins and Fine Chemicals, Nutley, NJ 07110 (Williams, Schcrf); and Basel, Switzerland (Frigg).

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J. H. White From the Department of Animal and Food Sciences, University of Vermont, Burlington, VT 05405 (Politis. Hidiroglou, White, Gilmore); Roche Vitamins and Fine Chemicals, Nutley, NJ 07110 (Williams, Schcrf); and Basel, Switzerland (Frigg).

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J. A. Gilmore From the Department of Animal and Food Sciences, University of Vermont, Burlington, VT 05405 (Politis. Hidiroglou, White, Gilmore); Roche Vitamins and Fine Chemicals, Nutley, NJ 07110 (Williams, Schcrf); and Basel, Switzerland (Frigg).

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S. N. Williams From the Department of Animal and Food Sciences, University of Vermont, Burlington, VT 05405 (Politis. Hidiroglou, White, Gilmore); Roche Vitamins and Fine Chemicals, Nutley, NJ 07110 (Williams, Schcrf); and Basel, Switzerland (Frigg).

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H. Scherf From the Department of Animal and Food Sciences, University of Vermont, Burlington, VT 05405 (Politis. Hidiroglou, White, Gilmore); Roche Vitamins and Fine Chemicals, Nutley, NJ 07110 (Williams, Schcrf); and Basel, Switzerland (Frigg).

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M. Frigg From the Department of Animal and Food Sciences, University of Vermont, Burlington, VT 05405 (Politis. Hidiroglou, White, Gilmore); Roche Vitamins and Fine Chemicals, Nutley, NJ 07110 (Williams, Schcrf); and Basel, Switzerland (Frigg).

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Abstract

Objective

To determine the effect of vitamin E supplementation on the immune system of dairy cows.

Design

The following immune parameters were followed: production of chemotactic factors and superoxide by mammary macrophages and chemotactic responsiveness of blood neutrophils.

Animals

16 healthy Holstein dairy cows.

Procedure

Dairy cows were assigned to 1 of 2 experimental groups: control (no vitamin E supplementation) and vitamin E supplemented. Supplementation of vitamin E started 4 weeks before and continued up to 8 weeks after parturition, and included oral supplementation of vitamin E at the rate of 3,000 IU/cow/d. In addition, the same group of cows received 1 injection of vitamin E (5,000 IU) 1 week prior to the expected date of parturition. Blood samples were collected weekly throughout the experimental period.

Results

Vitamin E supplementation enhanced by 30 to 83% (P < 0.05) chemotactic responsiveness of blood neutrophils beginning 2 weeks before to 4 weeks after parturition, compared with controls. There were no differences in production of superoxide or chemotactic factors by mammary macrophages between control and vitamin E-supplemented cows.

Conclusions

Vitamin E supplementation prevents the periparturient inhibition of neutrophil Chemotaxis. It is unlikely that vitamin E affects directly the function of mammary macrophages. (Am J Vet Res 1996;57:468–471)

Abstract

Objective

To determine the effect of vitamin E supplementation on the immune system of dairy cows.

Design

The following immune parameters were followed: production of chemotactic factors and superoxide by mammary macrophages and chemotactic responsiveness of blood neutrophils.

Animals

16 healthy Holstein dairy cows.

Procedure

Dairy cows were assigned to 1 of 2 experimental groups: control (no vitamin E supplementation) and vitamin E supplemented. Supplementation of vitamin E started 4 weeks before and continued up to 8 weeks after parturition, and included oral supplementation of vitamin E at the rate of 3,000 IU/cow/d. In addition, the same group of cows received 1 injection of vitamin E (5,000 IU) 1 week prior to the expected date of parturition. Blood samples were collected weekly throughout the experimental period.

Results

Vitamin E supplementation enhanced by 30 to 83% (P < 0.05) chemotactic responsiveness of blood neutrophils beginning 2 weeks before to 4 weeks after parturition, compared with controls. There were no differences in production of superoxide or chemotactic factors by mammary macrophages between control and vitamin E-supplemented cows.

Conclusions

Vitamin E supplementation prevents the periparturient inhibition of neutrophil Chemotaxis. It is unlikely that vitamin E affects directly the function of mammary macrophages. (Am J Vet Res 1996;57:468–471)

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