Use of plasma clearance of inulin for estimating glomerular filtration rate in cats

Scott Alan Brown From the Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602.

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 VMD, PhD
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Christopher Haberman From the Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602.

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Delmar R. Finco From the Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602.

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 DVM, PhD

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Abstract

Objective

To evaluate utility of a method for estimating glomerular filtration rate after a single IV injection of inulin.

Animals

Cats that were renal intact (n = 3) or had renal mass reduced by partial nephrectomy (n = 6).

Procedure

Plasma clearance of inulin (PCIn) was taken as the quotient of the administered dose of inulin (150 mg) divided by the area under the plasma inulin concentration versus time curve determined by 3 methods (PCIn1 – PCIn3). Results for PCIn were compared with simultaneously obtained values for urinary clearance of exogenous creatinine (CCr), an accepted method for the estimation of glomerular filtration rate (GFR) in cats.

Results

Values for PCIn were closely related (R2 ranged from 0.951 to 0.972, P < 0.0001 in all instances) to CCr. However, PCIn3 provided an estimate of GFR that consistently overestimated CCr.

Conclusion

Determination of PCIn by use of PCIn1 and PCIn2 provided a reliable estimate of GFR in cats of this study.

Clinical Relevance

Determination of PCIn appears to provide a reliable estimate of GFR in cats with early-stage renal disease and no evidence of derangement of body fluid status. In particular, PCIn2, which requires only 3 determinations of plasma inulin concentration, should be considered when an estimate of GFR is sought in a cat with suspected early-stage renal disease. (Am J Vet Res 1996;57:1702–1705)

Abstract

Objective

To evaluate utility of a method for estimating glomerular filtration rate after a single IV injection of inulin.

Animals

Cats that were renal intact (n = 3) or had renal mass reduced by partial nephrectomy (n = 6).

Procedure

Plasma clearance of inulin (PCIn) was taken as the quotient of the administered dose of inulin (150 mg) divided by the area under the plasma inulin concentration versus time curve determined by 3 methods (PCIn1 – PCIn3). Results for PCIn were compared with simultaneously obtained values for urinary clearance of exogenous creatinine (CCr), an accepted method for the estimation of glomerular filtration rate (GFR) in cats.

Results

Values for PCIn were closely related (R2 ranged from 0.951 to 0.972, P < 0.0001 in all instances) to CCr. However, PCIn3 provided an estimate of GFR that consistently overestimated CCr.

Conclusion

Determination of PCIn by use of PCIn1 and PCIn2 provided a reliable estimate of GFR in cats of this study.

Clinical Relevance

Determination of PCIn appears to provide a reliable estimate of GFR in cats with early-stage renal disease and no evidence of derangement of body fluid status. In particular, PCIn2, which requires only 3 determinations of plasma inulin concentration, should be considered when an estimate of GFR is sought in a cat with suspected early-stage renal disease. (Am J Vet Res 1996;57:1702–1705)

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