Effects of acepromazine maleate and phenoxybenzamine on urethral pressure profiles of anesthetized, healthy, sexually intact male cats

Steven L. Marks From the Departments of Veterinary Clinical Sciences (Marks, Straeter-Knowlen, Moore, Rishniw, Knowlen) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Ingrid M. Straeter-Knowlen From the Departments of Veterinary Clinical Sciences (Marks, Straeter-Knowlen, Moore, Rishniw, Knowlen) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Michael Moore From the Departments of Veterinary Clinical Sciences (Marks, Straeter-Knowlen, Moore, Rishniw, Knowlen) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Robert Speth From the Departments of Veterinary Clinical Sciences (Marks, Straeter-Knowlen, Moore, Rishniw, Knowlen) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Mark Rishniw From the Departments of Veterinary Clinical Sciences (Marks, Straeter-Knowlen, Moore, Rishniw, Knowlen) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Grant G. Knowlen From the Departments of Veterinary Clinical Sciences (Marks, Straeter-Knowlen, Moore, Rishniw, Knowlen) and Veterinary and Comparative Anatomy, Pharmacology, and Physiology (Speth), College of Veterinary Medicine, Washington State University, Pullman, WA 99164.

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Abstract

Objectives

To evaluate the effects of 2 compounds with α-adrenergic antagonist properties on the urethral pressures of anesthetized, healthy, sexually intact male cats, and to evaluate one of the compounds for effect on striated muscle.

Animals

20 healthy, sexually intact male cats.

Procedure

Cats were anesthetized with halothane, and urethral pressure profilometry was performed before and after treatment. 125l-labeled α-bungarotoxin bound to nicotinic receptors of murine skeletal muscle was used in a competitive binding study with acepromazine maleate.

Results

Acepromazine maleate significantly decreased intraurethral pressures in the preprostatic (19%) and pro-static (21%) regions of the urethra. There was no effect on the postprostatic/penile segment. Acepromazine did not inhibit 125l-labeled α-bungarotoxin binding to nicotinic receptors in murine skeletal muscle. Phenoxybenzamine significantly decreased intraurethral pressures (14%) in the preprostatic region of the urethra only.

Conclusions

Acepromazine maleate and phenoxy-benzamine have effects on the smooth muscle of the urethra of healthy, male cats. Acepromazine has no effect on striated muscle.

Clinical Relevance

α-Adrenergic compounds may be used in the pharmacologic management of feline urinary tract disease. (Am J Vet Res 1996;57:1497-1500)

Abstract

Objectives

To evaluate the effects of 2 compounds with α-adrenergic antagonist properties on the urethral pressures of anesthetized, healthy, sexually intact male cats, and to evaluate one of the compounds for effect on striated muscle.

Animals

20 healthy, sexually intact male cats.

Procedure

Cats were anesthetized with halothane, and urethral pressure profilometry was performed before and after treatment. 125l-labeled α-bungarotoxin bound to nicotinic receptors of murine skeletal muscle was used in a competitive binding study with acepromazine maleate.

Results

Acepromazine maleate significantly decreased intraurethral pressures in the preprostatic (19%) and pro-static (21%) regions of the urethra. There was no effect on the postprostatic/penile segment. Acepromazine did not inhibit 125l-labeled α-bungarotoxin binding to nicotinic receptors in murine skeletal muscle. Phenoxybenzamine significantly decreased intraurethral pressures (14%) in the preprostatic region of the urethra only.

Conclusions

Acepromazine maleate and phenoxy-benzamine have effects on the smooth muscle of the urethra of healthy, male cats. Acepromazine has no effect on striated muscle.

Clinical Relevance

α-Adrenergic compounds may be used in the pharmacologic management of feline urinary tract disease. (Am J Vet Res 1996;57:1497-1500)

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