Effect of glucocorticoids on serum osteocalcin concentration in horses

Raymond Geor From the Departments of Clinical and Population Sciences (Geor, Lauper, King) and Veterinary Diagnostic Medicine (Hope, Piela, Klassen, Murphy), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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 BVSc, MVSc
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Esther Hope From the Departments of Clinical and Population Sciences (Geor, Lauper, King) and Veterinary Diagnostic Medicine (Hope, Piela, Klassen, Murphy), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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 MS, DVM
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Linda Lauper From the Departments of Clinical and Population Sciences (Geor, Lauper, King) and Veterinary Diagnostic Medicine (Hope, Piela, Klassen, Murphy), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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Suzanne Piela From the Departments of Clinical and Population Sciences (Geor, Lauper, King) and Veterinary Diagnostic Medicine (Hope, Piela, Klassen, Murphy), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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Joan Klassen From the Departments of Clinical and Population Sciences (Geor, Lauper, King) and Veterinary Diagnostic Medicine (Hope, Piela, Klassen, Murphy), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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Vicky King From the Departments of Clinical and Population Sciences (Geor, Lauper, King) and Veterinary Diagnostic Medicine (Hope, Piela, Klassen, Murphy), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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Michael Murphy From the Departments of Clinical and Population Sciences (Geor, Lauper, King) and Veterinary Diagnostic Medicine (Hope, Piela, Klassen, Murphy), College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108.

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 DVM, PhD

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SUMMARY

The effects of dexamethasone (0.2 mg/kg of body weight; iv, im, and po) and methylprednisolone acetate (120 mg, given intra-articularly) on serum osteocalcin and cortisol concentrations were studied in 6 horses. Serum osteocalcin and cortisol concentrations were serially monitored after each treatment. A significant (P < 0.05) decrease in serum osteocalcin and cortisol concentrations was observed from 12 to 24 and 2 to 48 hours, respectively, after iv and im administrations of dexamethasone. Serum osteocalcin and cortisol concentrations were significantly decreased from 6 to 48 and 3 to 72 hours, respectively, after oral administration. In contrast, a change in serum osteocalcin concentration was not detected after intra-articular administration of methylprednisolone. Oral, iv, or im treatment with 0.2 mg of dexamethasone/kg caused a decrease in serum osteocalcin concentration in horses.

SUMMARY

The effects of dexamethasone (0.2 mg/kg of body weight; iv, im, and po) and methylprednisolone acetate (120 mg, given intra-articularly) on serum osteocalcin and cortisol concentrations were studied in 6 horses. Serum osteocalcin and cortisol concentrations were serially monitored after each treatment. A significant (P < 0.05) decrease in serum osteocalcin and cortisol concentrations was observed from 12 to 24 and 2 to 48 hours, respectively, after iv and im administrations of dexamethasone. Serum osteocalcin and cortisol concentrations were significantly decreased from 6 to 48 and 3 to 72 hours, respectively, after oral administration. In contrast, a change in serum osteocalcin concentration was not detected after intra-articular administration of methylprednisolone. Oral, iv, or im treatment with 0.2 mg of dexamethasone/kg caused a decrease in serum osteocalcin concentration in horses.

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