Effects of furosemide, exercise, and atropine on tracheal mucus transport rate in horses

Abby D. Maxson From the New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348-1692.

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Lawrence R. Soma From the New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348-1692.

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Laura L. May From the New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348-1692.

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Joli A. Martini From the New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348-1692.

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SUMMARY

Effects of furosemide, exercise, and atropine on tracheal mucus transport rate (tmtr) in horses were investigated. Atropine (0.02 mg/kg of body weight) administered iv or by aerosolization significantly (P < 0.05) decreased tmtr at 60, but not at 30 minutes after its administration in standing horses. Furosemide (1.0 mg/kg, iv) did not have any significant effect on tmtr when measured at 2 or 4 hours after its administration in standing horses. Exercise alone or furosemide (1.0 mg/kg, iv) administration followed 4 hours later by exercise did not alter tmtr, compared with values for standing control or exercised horses administered saline solution. Atropine (0.02 mg/kg, iv) administered after exercise significantly (P < 0.05) decreased tmtr, compared with values for no exercise standing controls, for exercise after administration of saline solution, and for furosemide and exercise.

SUMMARY

Effects of furosemide, exercise, and atropine on tracheal mucus transport rate (tmtr) in horses were investigated. Atropine (0.02 mg/kg of body weight) administered iv or by aerosolization significantly (P < 0.05) decreased tmtr at 60, but not at 30 minutes after its administration in standing horses. Furosemide (1.0 mg/kg, iv) did not have any significant effect on tmtr when measured at 2 or 4 hours after its administration in standing horses. Exercise alone or furosemide (1.0 mg/kg, iv) administration followed 4 hours later by exercise did not alter tmtr, compared with values for standing control or exercised horses administered saline solution. Atropine (0.02 mg/kg, iv) administered after exercise significantly (P < 0.05) decreased tmtr, compared with values for no exercise standing controls, for exercise after administration of saline solution, and for furosemide and exercise.

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