Effect of methacholine on mucociliary transport in bovine trachea in vitro

Maria H. Mars From the Department of Large Animal Medicine and Nutation, Veterinary Faculty, PO Box 80.152 3508 TD (Mars, Hajer, Breukink), and Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, PO Box 80.082, 3508 TB (Henncks), State University, Utrecht, The Netherlands.

Search for other papers by Maria H. Mars in
Current site
Google Scholar
PubMed
Close
 DVM
,
Paul A. J. Henricks From the Department of Large Animal Medicine and Nutation, Veterinary Faculty, PO Box 80.152 3508 TD (Mars, Hajer, Breukink), and Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, PO Box 80.082, 3508 TB (Henncks), State University, Utrecht, The Netherlands.

Search for other papers by Paul A. J. Henricks in
Current site
Google Scholar
PubMed
Close
 PhD
,
Rob Hajer From the Department of Large Animal Medicine and Nutation, Veterinary Faculty, PO Box 80.152 3508 TD (Mars, Hajer, Breukink), and Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, PO Box 80.082, 3508 TB (Henncks), State University, Utrecht, The Netherlands.

Search for other papers by Rob Hajer in
Current site
Google Scholar
PubMed
Close
 PhD
, and
Henk J. Breukink From the Department of Large Animal Medicine and Nutation, Veterinary Faculty, PO Box 80.152 3508 TD (Mars, Hajer, Breukink), and Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, PO Box 80.082, 3508 TB (Henncks), State University, Utrecht, The Netherlands.

Search for other papers by Henk J. Breukink in
Current site
Google Scholar
PubMed
Close
 PhD

Click on author name to view affiliation information

Abstract

A method is described to evaluate pharmacologic influence on bovine tracheal mucus transport in vitro. In this model, cholinergic agonist methacholine stimulated transport velocity. Methacholine at concentration of 10−6M increased velocity by 13.6%, whereas 10−5M increased velocity by 26%. Stimulation was inhibited by atropine.

Abstract

A method is described to evaluate pharmacologic influence on bovine tracheal mucus transport in vitro. In this model, cholinergic agonist methacholine stimulated transport velocity. Methacholine at concentration of 10−6M increased velocity by 13.6%, whereas 10−5M increased velocity by 26%. Stimulation was inhibited by atropine.

All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 35 35 9
PDF Downloads 14 14 1
Advertisement