Diet effect on activity product ratios of uric acid, sodium urate, and ammonium urate in urine formed by healthy Beagles

Joseph W. Bartges From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Carl A. Osborne From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Lawrence J. Felice From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Timothy A. Allen From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Charles Brown From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Lisa K. Unger From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Lori A. Koehler From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Kathy A. Bird From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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Menglan Chen From the Department of Small Animal Clinical Sciences (Bartges, Osborne, Unger, Koehler, Bird), and Laboratory for Veterinary Diagnostic Medicine (Felice, Chen), College of Veterinary Medicine, University of Minnesota, 1352 Boyd Ave, St Paul, MN 55108; Mark Moms Associates, 5500 SW 7th St, Topeka, KS 66606 (Allen); and the Department of Molecular Biology and Biochemistry, College of Medicine, University of Florida, Gainesville, FL 32610 (Brown).

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SUMMARY

Urine activity product ratios of uric acid, sodium urate, and ammonium urate and urinary excretion of metabolites were determined in 24-hour samples produced by 6 healthy Beagles during periods of consumption of a low-protein, casein-based diet (diet A) and a high-protein, meat-based diet (diet B). Comparison of effects of diet A with those of diet B revealed: significantly lower activity product ratios of uric acid (P = 0.025), sodium urate (P = 0.045), and ammonium urate (P = 0.0045); significantly lower 24-hour urinary excretion of uric acid (P = 0.002), ammonia (P = 0.0002), sodium (P = 0.01), calcium (P = 0.005), phosphorus (P = 0.0003), magnesium (P = 0.01), and oxalic acid (P = 0.004); significantly (P = 0.0001) higher 24-hour urine pH; and significantly (P = 0.01) lower endogenous creatinine clearance. These results suggest that consumption of diet A minimizes changes in urine that predispose dogs to uric acid, sodium urate, and ammonium urate urolithiasis.

SUMMARY

Urine activity product ratios of uric acid, sodium urate, and ammonium urate and urinary excretion of metabolites were determined in 24-hour samples produced by 6 healthy Beagles during periods of consumption of a low-protein, casein-based diet (diet A) and a high-protein, meat-based diet (diet B). Comparison of effects of diet A with those of diet B revealed: significantly lower activity product ratios of uric acid (P = 0.025), sodium urate (P = 0.045), and ammonium urate (P = 0.0045); significantly lower 24-hour urinary excretion of uric acid (P = 0.002), ammonia (P = 0.0002), sodium (P = 0.01), calcium (P = 0.005), phosphorus (P = 0.0003), magnesium (P = 0.01), and oxalic acid (P = 0.004); significantly (P = 0.0001) higher 24-hour urine pH; and significantly (P = 0.01) lower endogenous creatinine clearance. These results suggest that consumption of diet A minimizes changes in urine that predispose dogs to uric acid, sodium urate, and ammonium urate urolithiasis.

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