Effects of medetomidine administration on intracranial pressure and cardiovascular variables of isoflurane-anesthetized dogs

Robert D. Keegan From the Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 (Keegan, Greene, Bagley, Moore, Weil), and the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Short).

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Stephen A. Greene From the Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 (Keegan, Greene, Bagley, Moore, Weil), and the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Short).

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Rodney S. Bagley From the Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 (Keegan, Greene, Bagley, Moore, Weil), and the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Short).

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Michael P. Moore From the Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 (Keegan, Greene, Bagley, Moore, Weil), and the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Short).

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Ann B. Weil From the Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 (Keegan, Greene, Bagley, Moore, Weil), and the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Short).

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Charles E. Short From the Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 (Keegan, Greene, Bagley, Moore, Weil), and the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 (Short).

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SUMMARY

Intracranial pressure and cardiovascular variables after iv administration of medetomidine (0.03 mg/kg of body weight) were evaluated in 6 healthy, mixed-breed dogs anesthetized with 1.3% end-tidal isoflurane concentration and mechanically ventilated to normocapnia (PaCO2, 35 to 45 mm of Hg). Baseline values were determined for intracranial pressure, heart rate, arterial blood pressure, cardiac output, mean pulmonary artery pressure, pulmonary capillary wedge pressure, central venous pressure, end-tidal CO2 tension and isoflurane concentration, arterial pH and CO2 and O2 tensions, and core body temperature. Cerebral perfusion pressure, cardiac index, systemic and pulmonary vascular resistances, plasma HCO3- concentration, and base excess were calculated. Intracranial pressure was measured, using a calibrated, fiberoptic transducer placed within the brain parenchyma and secured to the calvarium by means of a subarachnoid bolt. Cardiac output was determined by thermodilution. End-tidal CO2 tension and isoflurane concentration were determined, using an infrared gas analyzer. Administration of medetomidine did not change intracranial pressure, but was associated with significant (P < 0.05) decreases in values for heart rate, cardiac index, end-tidal CO2, and HCO3- and with significant increases in systolic, mean, and diastolic pressure; pulmonary artery pressure; systemic vascular resistance; central venous pressure; and pulmonary capillary wedge pressure.

SUMMARY

Intracranial pressure and cardiovascular variables after iv administration of medetomidine (0.03 mg/kg of body weight) were evaluated in 6 healthy, mixed-breed dogs anesthetized with 1.3% end-tidal isoflurane concentration and mechanically ventilated to normocapnia (PaCO2, 35 to 45 mm of Hg). Baseline values were determined for intracranial pressure, heart rate, arterial blood pressure, cardiac output, mean pulmonary artery pressure, pulmonary capillary wedge pressure, central venous pressure, end-tidal CO2 tension and isoflurane concentration, arterial pH and CO2 and O2 tensions, and core body temperature. Cerebral perfusion pressure, cardiac index, systemic and pulmonary vascular resistances, plasma HCO3- concentration, and base excess were calculated. Intracranial pressure was measured, using a calibrated, fiberoptic transducer placed within the brain parenchyma and secured to the calvarium by means of a subarachnoid bolt. Cardiac output was determined by thermodilution. End-tidal CO2 tension and isoflurane concentration were determined, using an infrared gas analyzer. Administration of medetomidine did not change intracranial pressure, but was associated with significant (P < 0.05) decreases in values for heart rate, cardiac index, end-tidal CO2, and HCO3- and with significant increases in systolic, mean, and diastolic pressure; pulmonary artery pressure; systemic vascular resistance; central venous pressure; and pulmonary capillary wedge pressure.

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